Progress in aorta and peripheral cardiovascular disease research
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Progress in aorta and peripheral cardiovascular disease research. / Mazzolai, Lucia; Alatri, Adriano; Rivière, Alessandra Bura; De Carlo, Marco; Heiss, Christian; Espinola-Klein, Christine; Schlager, Oliver; Sillesen, Henrik; Staub, Daniel; Rodriguez-Palomares, José F.; Verstraeten, Aline; Aboyans, Victor.
In: Cardiovascular Research, Vol. 117, No. 9, 2021, p. 2045-2053.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Progress in aorta and peripheral cardiovascular disease research
AU - Mazzolai, Lucia
AU - Alatri, Adriano
AU - Rivière, Alessandra Bura
AU - De Carlo, Marco
AU - Heiss, Christian
AU - Espinola-Klein, Christine
AU - Schlager, Oliver
AU - Sillesen, Henrik
AU - Staub, Daniel
AU - Rodriguez-Palomares, José F.
AU - Verstraeten, Aline
AU - Aboyans, Victor
N1 - Publisher Copyright: © 2021 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for a protein/lipid-based FMD blood test. The role of NADPH oxidases in vascular physiology, and particularly endothelial cell differentiation, is highlighted with potential for cell therapy development. Imaging of vulnerable plaque has been an intense field of research. Features of plaque vulnerability on magnetic resonance imaging as an under-recognized cause of stroke are discussed. Major clinical trials on lower extremity peripheral artery disease have shown added benefit of dual antithrombotic (aspirin plus rivaroxaban) treatment.
AB - Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for a protein/lipid-based FMD blood test. The role of NADPH oxidases in vascular physiology, and particularly endothelial cell differentiation, is highlighted with potential for cell therapy development. Imaging of vulnerable plaque has been an intense field of research. Features of plaque vulnerability on magnetic resonance imaging as an under-recognized cause of stroke are discussed. Major clinical trials on lower extremity peripheral artery disease have shown added benefit of dual antithrombotic (aspirin plus rivaroxaban) treatment.
KW - Antithrombotics
KW - Aorta
KW - COVID
KW - Peripheral artery disease
KW - Venous thromboembolism
U2 - 10.1093/cvr/cvab144
DO - 10.1093/cvr/cvab144
M3 - Review
C2 - 33892507
AN - SCOPUS:85112446145
VL - 117
SP - 2045
EP - 2053
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 9
ER -
ID: 303576741