Prognostic importance of culprit lesion location in cardiogenic shock due to myocardial infarction
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Prognostic importance of culprit lesion location in cardiogenic shock due to myocardial infarction. / Josiassen, Jakob; Helgestad, Ole K. L.; Møller, Jacob E.; Holmvang, Lene; Jensen, Lisette O; Udesen, Nanna L. J.; Ravn, Hanne B.; Hassager, Christian.
In: European Heart Journal: Acute Cardiovascular Care, Vol. 10, No. 1, 2021, p. 25-32.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prognostic importance of culprit lesion location in cardiogenic shock due to myocardial infarction
AU - Josiassen, Jakob
AU - Helgestad, Ole K. L.
AU - Møller, Jacob E.
AU - Holmvang, Lene
AU - Jensen, Lisette O
AU - Udesen, Nanna L. J.
AU - Ravn, Hanne B.
AU - Hassager, Christian
PY - 2021
Y1 - 2021
N2 - Background:As existing results are diverging, and the patient population has changed significantly, this study sought to investigate the prognostic importance of the culprit lesion location in patients with cardiogenic shock due to myocardial infarction (AMICS), in a contemporary and unselected patient population.Methods:From the recruitment area of two tertiary heart centres in Denmark, covering 3.9 million citizens corresponding to two-thirds of the Danish population, all AMICS patients in the period of 2010-2017 were individually identified and validated through patient records.Results:A total of 1716 patients with AMICS were identified. Immediate revascularization was performed in 1482 patients (86%). Among these, a culprit lesion in the left main coronary artery (LM) was associated with the highest 30-day mortality rate (66%), p(logrank)Conclusions:Among AMICS patients undergoing revascularization, a LM culprit lesion was associated with the highest short-term mortality, whereas patients with a culprit lesion in the remaining coronary arteries had comparable and lower mortality rates. Multivessel disease patients had similar prognoses irrespective of percutaneous coronary intervention approach and whether partial or complete revascularization was achieved.
AB - Background:As existing results are diverging, and the patient population has changed significantly, this study sought to investigate the prognostic importance of the culprit lesion location in patients with cardiogenic shock due to myocardial infarction (AMICS), in a contemporary and unselected patient population.Methods:From the recruitment area of two tertiary heart centres in Denmark, covering 3.9 million citizens corresponding to two-thirds of the Danish population, all AMICS patients in the period of 2010-2017 were individually identified and validated through patient records.Results:A total of 1716 patients with AMICS were identified. Immediate revascularization was performed in 1482 patients (86%). Among these, a culprit lesion in the left main coronary artery (LM) was associated with the highest 30-day mortality rate (66%), p(logrank)Conclusions:Among AMICS patients undergoing revascularization, a LM culprit lesion was associated with the highest short-term mortality, whereas patients with a culprit lesion in the remaining coronary arteries had comparable and lower mortality rates. Multivessel disease patients had similar prognoses irrespective of percutaneous coronary intervention approach and whether partial or complete revascularization was achieved.
KW - Cardiogenic shock
KW - myocardial infarction
KW - left main
KW - multivessel disease
KW - revascularization
KW - acute heart failure
KW - PERCUTANEOUS CORONARY INTERVENTION
KW - ANGIOGRAPHIC FINDINGS
KW - CARDIAC-ARREST
KW - PRIMARY PCI
KW - MULTIVESSEL
KW - MORTALITY
KW - REGISTRY
KW - ASSOCIATION
KW - SURVIVAL
KW - DISEASE
U2 - 10.1177/2048872620911848
DO - 10.1177/2048872620911848
M3 - Journal article
VL - 10
SP - 25
EP - 32
JO - European Heart Journal: Acute Cardiovascular Care
JF - European Heart Journal: Acute Cardiovascular Care
SN - 2048-8726
IS - 1
ER -
ID: 302820367