Primary prevention of skin dysplasia in renal transplant recipients with photodynamic therapy: a randomized controlled trial
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Primary prevention of skin dysplasia in renal transplant recipients with photodynamic therapy : a randomized controlled trial. / Togsverd-Bo, K; Omland, S H; Wulf, H C; Sørensen, S S; Haedersdal, M.
In: American Journal of Transplantation, Vol. 15, No. 11, 11.2015, p. 2986-90.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Primary prevention of skin dysplasia in renal transplant recipients with photodynamic therapy
T2 - a randomized controlled trial
AU - Togsverd-Bo, K
AU - Omland, S H
AU - Wulf, H C
AU - Sørensen, S S
AU - Haedersdal, M
N1 - © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.
PY - 2015/11
Y1 - 2015/11
N2 - Organ transplant recipients (OTRs) are at high risk of developing cutaneous squamous cell carcinoma (SCC); prevention includes early treatment of premalignant actinic keratosis (AK). Photodynamic therapy (PDT) is a noninvasive field therapy that reduces new AKs in patients with existing AK and delays SCC development in mice. We investigated the effect of repeated PDT over 5 years for primary prophylaxis of skin dysplasia. These data represent an interim analysis of an on-going randomized controlled trial. During 2008-2011, 25 renal transplant recipients with clinically normal skin were randomized to split-side PDT of the face, forearm and hand, the contralateral side serving as untreated control. Patients received PDT on inclusion and at 6-monthly intervals for 5 years. Blinded evaluation was performed at each visit. We found that prophylactic PDT significantly delayed onset of AK compared with untreated skin, p = 0.020. At 3-year follow-up, we observed AK in 63% of patients in untreated skin areas compared with 28% of patients in PDT-treated skin, with a total number of cumulated AKs in untreated skin (n = 43) compared with PDT-treated skin (n = 8), p = 0.005. These preliminary data indicate a novel approach to early prevention of skin dysplasia that may reduce morbidity from multiple AKs and SCCs in OTR.
AB - Organ transplant recipients (OTRs) are at high risk of developing cutaneous squamous cell carcinoma (SCC); prevention includes early treatment of premalignant actinic keratosis (AK). Photodynamic therapy (PDT) is a noninvasive field therapy that reduces new AKs in patients with existing AK and delays SCC development in mice. We investigated the effect of repeated PDT over 5 years for primary prophylaxis of skin dysplasia. These data represent an interim analysis of an on-going randomized controlled trial. During 2008-2011, 25 renal transplant recipients with clinically normal skin were randomized to split-side PDT of the face, forearm and hand, the contralateral side serving as untreated control. Patients received PDT on inclusion and at 6-monthly intervals for 5 years. Blinded evaluation was performed at each visit. We found that prophylactic PDT significantly delayed onset of AK compared with untreated skin, p = 0.020. At 3-year follow-up, we observed AK in 63% of patients in untreated skin areas compared with 28% of patients in PDT-treated skin, with a total number of cumulated AKs in untreated skin (n = 43) compared with PDT-treated skin (n = 8), p = 0.005. These preliminary data indicate a novel approach to early prevention of skin dysplasia that may reduce morbidity from multiple AKs and SCCs in OTR.
U2 - 10.1111/ajt.13358
DO - 10.1111/ajt.13358
M3 - Journal article
C2 - 26018207
VL - 15
SP - 2986
EP - 2990
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 11
ER -
ID: 160480950