Prevalence of optic disc drusen: A systematic review, meta-analysis and forecasting study
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Prevalence of optic disc drusen : A systematic review, meta-analysis and forecasting study. / Mukriyani, Hiwa; Malmqvist, Lasse; Subhi, Yousif; Hamann, Steffen.
In: Acta Ophthalmologica, Vol. 102, No. 1, 2024, p. 15-24.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Prevalence of optic disc drusen
T2 - A systematic review, meta-analysis and forecasting study
AU - Mukriyani, Hiwa
AU - Malmqvist, Lasse
AU - Subhi, Yousif
AU - Hamann, Steffen
N1 - Publisher Copyright: © 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
PY - 2024
Y1 - 2024
N2 - Optic disc drusen (ODD) are calcium-containing deposits in the optic nerve head, capable of causing visual field defects and sudden visual loss. The underlying pathophysiology remains inadequately understood and treatment options are missing. In this paper, we systematically reviewed prevalence studies of ODD in non-selected populations to provide an overview of its prevalence, conducted meta-analyses to determine modality-specific prevalence estimates and performed a forecasting study to estimate current and future global population number of individuals with ODD. We searched 11 literature databases on 25 October 2022 for prevalence studies of ODD in non-selected populations. Eight eligible studies provided data from a total of 27 463 individuals. Prevalence estimates were stratified according to diagnostic modalities: ophthalmoscopy 0.37% (95% CI: 0.10–0.95%), fundus photography 0.12% (95% CI: 0.03–0.24%), spectral domain optical coherence tomography with enhanced depth imaging 2.21% (95% CI: 1.25–3.42%) and histopathology 1.82% (95% CI: 1.32–2.38%). Using histopathology-based summary prevalence estimate, we forecast 145 million individuals with ODD currently, a number expected to increase further due to world population growth. These numbers underscore the importance of including ODD in health education and highlight the necessity of continuing research in ODD.
AB - Optic disc drusen (ODD) are calcium-containing deposits in the optic nerve head, capable of causing visual field defects and sudden visual loss. The underlying pathophysiology remains inadequately understood and treatment options are missing. In this paper, we systematically reviewed prevalence studies of ODD in non-selected populations to provide an overview of its prevalence, conducted meta-analyses to determine modality-specific prevalence estimates and performed a forecasting study to estimate current and future global population number of individuals with ODD. We searched 11 literature databases on 25 October 2022 for prevalence studies of ODD in non-selected populations. Eight eligible studies provided data from a total of 27 463 individuals. Prevalence estimates were stratified according to diagnostic modalities: ophthalmoscopy 0.37% (95% CI: 0.10–0.95%), fundus photography 0.12% (95% CI: 0.03–0.24%), spectral domain optical coherence tomography with enhanced depth imaging 2.21% (95% CI: 1.25–3.42%) and histopathology 1.82% (95% CI: 1.32–2.38%). Using histopathology-based summary prevalence estimate, we forecast 145 million individuals with ODD currently, a number expected to increase further due to world population growth. These numbers underscore the importance of including ODD in health education and highlight the necessity of continuing research in ODD.
KW - meta-analysis
KW - optic disc drusen
KW - optic nerve head drusen
KW - prevalence
KW - Pseudopapilledema
KW - systematic review
U2 - 10.1111/aos.15690
DO - 10.1111/aos.15690
M3 - Review
C2 - 37144704
AN - SCOPUS:85158100224
VL - 102
SP - 15
EP - 24
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 1
ER -
ID: 379653065