Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication
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Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes : Sex differences in symptomatology and prediction of future anti-depressive medication. / Mikkelsen, Christina; Larsen, Margit A.H.; Sørensen, Erik; Hansen, Thomas Folkmann; Mikkelsen, Susan; Erikstrup, Christian; Nielsen, Kaspar R.; Bruun, Mie T.; Hjalgrim, Henrik; Kessing, Lars V.; Werge, Thomas; Ullum, Henrik; Ostrowski, Sisse R.; Pedersen, Ole B.; Thørner, Lise W.; Didriksen, Maria.
In: Psychiatry Research, Vol. 318, 114944, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes
T2 - Sex differences in symptomatology and prediction of future anti-depressive medication
AU - Mikkelsen, Christina
AU - Larsen, Margit A.H.
AU - Sørensen, Erik
AU - Hansen, Thomas Folkmann
AU - Mikkelsen, Susan
AU - Erikstrup, Christian
AU - Nielsen, Kaspar R.
AU - Bruun, Mie T.
AU - Hjalgrim, Henrik
AU - Kessing, Lars V.
AU - Werge, Thomas
AU - Ullum, Henrik
AU - Ostrowski, Sisse R.
AU - Pedersen, Ole B.
AU - Thørner, Lise W.
AU - Didriksen, Maria
N1 - Publisher Copyright: © 2022
PY - 2022
Y1 - 2022
N2 - Major Depressive Disorder (MDD) is a heterogeneous disease, which displays sex differences in symptomatology. This study aimed to assess point prevalence of MDD in undiagnosed, healthy adults as well as sex differences in symptomatology and clarify if specific symptoms increased the later need for anti-depressive medication. The study included 51,658 blood donors. Depressive symptoms were assessed according to ICD-10 using the Major Depression Inventory. Demographics, previous MDD, anti-depressive medication were collected from questionnaires and population registers. Descriptive, Logistic and Cox regression analyses were conducted. In total, 1.15% participants met the criteria for MDD. Women were significantly more likely to experience "increased appetite" and less likely to experience “a feeling of life not worth living”, compared to men. MDD significantly associated with an increased hazard of later receiving a prescription for anti-depressive medication. The risk increased proportionally with increasing MDD severity. The two symptoms, “feeling that life is not worth living” and "trouble sleeping" were the strongest individual predictive symptoms of future anti-depressive medication in women and men, respectively. The results confirm findings in MDD patient groups. The diagnostic and prognostic value should be investigated further to address their potential as part of the clinical assessment.
AB - Major Depressive Disorder (MDD) is a heterogeneous disease, which displays sex differences in symptomatology. This study aimed to assess point prevalence of MDD in undiagnosed, healthy adults as well as sex differences in symptomatology and clarify if specific symptoms increased the later need for anti-depressive medication. The study included 51,658 blood donors. Depressive symptoms were assessed according to ICD-10 using the Major Depression Inventory. Demographics, previous MDD, anti-depressive medication were collected from questionnaires and population registers. Descriptive, Logistic and Cox regression analyses were conducted. In total, 1.15% participants met the criteria for MDD. Women were significantly more likely to experience "increased appetite" and less likely to experience “a feeling of life not worth living”, compared to men. MDD significantly associated with an increased hazard of later receiving a prescription for anti-depressive medication. The risk increased proportionally with increasing MDD severity. The two symptoms, “feeling that life is not worth living” and "trouble sleeping" were the strongest individual predictive symptoms of future anti-depressive medication in women and men, respectively. The results confirm findings in MDD patient groups. The diagnostic and prognostic value should be investigated further to address their potential as part of the clinical assessment.
KW - Epidemiology
KW - Mental health
U2 - 10.1016/j.psychres.2022.114944
DO - 10.1016/j.psychres.2022.114944
M3 - Journal article
C2 - 36402070
AN - SCOPUS:85141984603
VL - 318
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
M1 - 114944
ER -
ID: 327322208