Prevalence of early stages of heart failure in an elderly risk population: The Copenhagen Heart Failure Risk Study
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Prevalence of early stages of heart failure in an elderly risk population : The Copenhagen Heart Failure Risk Study. / Gaborit, Freja Stoltze; Kistorp, Caroline; Kümler, Thomas; Hassager, Christian; Tønder, Niels; Køber, Lars; Hansen, Pernille Mørk; Kamstrup, Pia Rørbæk; Faber, Jens; Iversen, Kasper Karmark; Schou, Morten.
In: Open Heart, Vol. 6, No. 1, e000840, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prevalence of early stages of heart failure in an elderly risk population
T2 - The Copenhagen Heart Failure Risk Study
AU - Gaborit, Freja Stoltze
AU - Kistorp, Caroline
AU - Kümler, Thomas
AU - Hassager, Christian
AU - Tønder, Niels
AU - Køber, Lars
AU - Hansen, Pernille Mørk
AU - Kamstrup, Pia Rørbæk
AU - Faber, Jens
AU - Iversen, Kasper Karmark
AU - Schou, Morten
PY - 2019
Y1 - 2019
N2 - Aims To describe the prevalence of heart failure (HF) stages in elderly outpatients with risk factors for HF but without known HF, and characterise the clinical, biochemical and echocardiographic findings in each stage. Background Early stages of HF are underdiagnosed; nevertheless, they are associated with an increased risk of hospitalisation and increased mortality. The prevalence of HF stages in elderly high-risk patients is unknown. Methods A total of 400 patients were consecutively included: ≥60 years old, ≥1 risk factor for HF (diabetes, chronic kidney disease, cardiovascular disease, atrial fibrillation, hypertension), and without known or suspected HF. HF stages were defined as the following: Stage A (risk factor for HF, normal echocardiography), stage B (abnormal echocardiography, without symptoms of HF) and stage C (abnormal echocardiography, symptoms of HF, clinical signs/increased plasma aminoterminal pro-B-type natriuretic peptide [NT-proBNP] concentrations). Results After thorough examination 44.25% of patients were categorised as HF stage A, 37.5% were HF stage B and 18.25% HF stage C. Those with higher stages of HF were older (p<0.001) and more often had atrial fibrillation (p=0.006). The median plasma NT-proBNP concentrations (pg/mL) were 132.5 for HF stage A, 275.5 for HF stage B and 400.0 for HF stage C (p<0.001). Detectable plasma troponin-I was more frequent with abnormal echocardiography: HF stage A 9.7%, HF stage B 27.3% and HF stage C 30.1% (p<0.001). HF stage C reported higher score on the Minnesota Living with Heart Failure Questionnaire (p<0.001). Conclusions In an elderly high-risk population without known or suspected HF, more than half were HF stage B or C. Higher stages of HF had increased plasma concentrations of NT-proBNP and troponin-I, besides a reduced quality of life. Focus on symptoms and signs of HF in this population are warranted.
AB - Aims To describe the prevalence of heart failure (HF) stages in elderly outpatients with risk factors for HF but without known HF, and characterise the clinical, biochemical and echocardiographic findings in each stage. Background Early stages of HF are underdiagnosed; nevertheless, they are associated with an increased risk of hospitalisation and increased mortality. The prevalence of HF stages in elderly high-risk patients is unknown. Methods A total of 400 patients were consecutively included: ≥60 years old, ≥1 risk factor for HF (diabetes, chronic kidney disease, cardiovascular disease, atrial fibrillation, hypertension), and without known or suspected HF. HF stages were defined as the following: Stage A (risk factor for HF, normal echocardiography), stage B (abnormal echocardiography, without symptoms of HF) and stage C (abnormal echocardiography, symptoms of HF, clinical signs/increased plasma aminoterminal pro-B-type natriuretic peptide [NT-proBNP] concentrations). Results After thorough examination 44.25% of patients were categorised as HF stage A, 37.5% were HF stage B and 18.25% HF stage C. Those with higher stages of HF were older (p<0.001) and more often had atrial fibrillation (p=0.006). The median plasma NT-proBNP concentrations (pg/mL) were 132.5 for HF stage A, 275.5 for HF stage B and 400.0 for HF stage C (p<0.001). Detectable plasma troponin-I was more frequent with abnormal echocardiography: HF stage A 9.7%, HF stage B 27.3% and HF stage C 30.1% (p<0.001). HF stage C reported higher score on the Minnesota Living with Heart Failure Questionnaire (p<0.001). Conclusions In an elderly high-risk population without known or suspected HF, more than half were HF stage B or C. Higher stages of HF had increased plasma concentrations of NT-proBNP and troponin-I, besides a reduced quality of life. Focus on symptoms and signs of HF in this population are warranted.
KW - echocardiography
KW - elderly
KW - heart failure
KW - hf stages
KW - high-risk populations
U2 - 10.1136/openhrt-2018-000840
DO - 10.1136/openhrt-2018-000840
M3 - Journal article
C2 - 30997116
AN - SCOPUS:85062291646
VL - 6
JO - Open Heart
JF - Open Heart
SN - 2398-595X
IS - 1
M1 - e000840
ER -
ID: 223573043