Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV
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Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV. / Knudsen, Andreas Dehlbæk; Kofoed, Klaus Fuglsang; Gelpi, Marco; Sigvardsen, Per Ejlstrup; Mocroft, Amanda; Kühl, Jørgen Tobias; Fuchs, Andreas; Køber, Lars; Nordestgaard, Børge G; Benfield, Thomas; Graff, Claus; Skov, Morten Wagner; Lundgren, Jens; Nielsen, Susanne Dam; Copenhagen Comorbidity in HIV Infection (COCOMO) Study.
In: AIDS, Vol. 33, No. 14, 2019, p. 2205-2210.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV
AU - Knudsen, Andreas Dehlbæk
AU - Kofoed, Klaus Fuglsang
AU - Gelpi, Marco
AU - Sigvardsen, Per Ejlstrup
AU - Mocroft, Amanda
AU - Kühl, Jørgen Tobias
AU - Fuchs, Andreas
AU - Køber, Lars
AU - Nordestgaard, Børge G
AU - Benfield, Thomas
AU - Graff, Claus
AU - Skov, Morten Wagner
AU - Lundgren, Jens
AU - Nielsen, Susanne Dam
AU - Copenhagen Comorbidity in HIV Infection (COCOMO) Study
PY - 2019
Y1 - 2019
N2 - OBJECTIVE: Abnormal ECGs are associated with increased risk of arrhythmias and sudden cardiac death. We aimed to investigate the prevalence and associated risk factors of prolonged QTc and major ECG abnormalities, in persons living with HIV (PLWH) and uninfected controls.DESIGN: PLWH aged at least 40 years were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study and matched on sex and age to uninfected controls from the Copenhagen General Population Study.METHODS: ECGs were categorized according to Minnesota Code Manual of ECG Findings definition of major abnormalities. A QT interval corrected for heart rate (QTc) greater than 440 ms in men and greater than 460 ms in women was considered prolonged. Pathologic Q-waves were defined as presence of major Q-wave abnormalities.RESULTS: ECGs were available for 745 PLWH and 2977 controls. Prolonged QTc was prevalent in 9% of PLWH and 6% of controls, P = 0.052. Pathologic Q-waves were more common in PLWH (6%) than in controls (4%), P = 0.028. There was no difference in prevalence of major ECG abnormalities between PLWH and controls, P = 0.987.In adjusted analyses, HIV was associated with a 3.6 ms (1.8-5.4) longer QTc interval, P < 0.001, and HIV was independently associated with prolonged QTc [adjusted odds ratio: 1.59 (1.14-2.19)], P = 0.005. HIV was borderline associated to pathologic Q-waves after adjusting, P = 0.051.CONCLUSION: HIV was associated with higher odds ratio of prolonged QTc after adjustment for cardiovascular risk factors, but analyses were not adjusted for QT-prolonging medication. Although evidence indicated more pathologic Q-waves in PLWH, the risk seemed to be associated mainly with an adverse risk profile.
AB - OBJECTIVE: Abnormal ECGs are associated with increased risk of arrhythmias and sudden cardiac death. We aimed to investigate the prevalence and associated risk factors of prolonged QTc and major ECG abnormalities, in persons living with HIV (PLWH) and uninfected controls.DESIGN: PLWH aged at least 40 years were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study and matched on sex and age to uninfected controls from the Copenhagen General Population Study.METHODS: ECGs were categorized according to Minnesota Code Manual of ECG Findings definition of major abnormalities. A QT interval corrected for heart rate (QTc) greater than 440 ms in men and greater than 460 ms in women was considered prolonged. Pathologic Q-waves were defined as presence of major Q-wave abnormalities.RESULTS: ECGs were available for 745 PLWH and 2977 controls. Prolonged QTc was prevalent in 9% of PLWH and 6% of controls, P = 0.052. Pathologic Q-waves were more common in PLWH (6%) than in controls (4%), P = 0.028. There was no difference in prevalence of major ECG abnormalities between PLWH and controls, P = 0.987.In adjusted analyses, HIV was associated with a 3.6 ms (1.8-5.4) longer QTc interval, P < 0.001, and HIV was independently associated with prolonged QTc [adjusted odds ratio: 1.59 (1.14-2.19)], P = 0.005. HIV was borderline associated to pathologic Q-waves after adjusting, P = 0.051.CONCLUSION: HIV was associated with higher odds ratio of prolonged QTc after adjustment for cardiovascular risk factors, but analyses were not adjusted for QT-prolonging medication. Although evidence indicated more pathologic Q-waves in PLWH, the risk seemed to be associated mainly with an adverse risk profile.
U2 - 10.1097/QAD.0000000000002327
DO - 10.1097/QAD.0000000000002327
M3 - Journal article
C2 - 31373917
VL - 33
SP - 2205
EP - 2210
JO - AIDS
JF - AIDS
SN - 1350-2840
IS - 14
ER -
ID: 237849913