Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver. / Henriksen, Jens Henrik Sahl; Lassen, N A.

In: Liver, Vol. 8, No. 2, 1988, p. 88-94.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Henriksen, JHS & Lassen, NA 1988, 'Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver', Liver, vol. 8, no. 2, pp. 88-94.

APA

Henriksen, J. H. S., & Lassen, N. A. (1988). Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver. Liver, 8(2), 88-94.

Vancouver

Henriksen JHS, Lassen NA. Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver. Liver. 1988;8(2):88-94.

Author

Henriksen, Jens Henrik Sahl ; Lassen, N A. / Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver. In: Liver. 1988 ; Vol. 8, No. 2. pp. 88-94.

Bibtex

@article{e852e6a0333311df8ed1000ea68e967b,
title = "Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver",
abstract = "A model of pressure profile along the sinusoids in the liver is presented. The major prerequisite is a converging sinusoidal flow pattern through a network of tubes with almost equal diameter. In this case the main hemodynamic resistance is located downstream at the outlet. Different geometric configurations (sphere, cylinder, and sections of these) are considered, and it is concluded that the precise shape of the microcirculatory unit is not crucial. The applicability in cirrhosis is considered in relation to a decreased diameter and number of the sinusoids in this condition. Estimated pressure profiles along the sinusoids indicate a steep downstream pressure fall in cirrhosis, implying that the spatial average of sinusoidal pressure is close to that of the inlet, i.e. portal pressure. Another prediction is an increased blood flow rate (flow rate per vessel) in the region near the outlet of the sinusoids.",
author = "Henriksen, {Jens Henrik Sahl} and Lassen, {N A}",
note = "Keywords: Blood Pressure; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Microcirculation; Models, Biological; Vascular Resistance",
year = "1988",
language = "English",
volume = "8",
pages = "88--94",
journal = "Liver",
issn = "0106-9543",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Pressure profile in liver sinusoids. A model of localization of sinusoidal resistance in the normal and cirrhotic liver

AU - Henriksen, Jens Henrik Sahl

AU - Lassen, N A

N1 - Keywords: Blood Pressure; Humans; Hypertension, Portal; Liver Circulation; Liver Cirrhosis; Microcirculation; Models, Biological; Vascular Resistance

PY - 1988

Y1 - 1988

N2 - A model of pressure profile along the sinusoids in the liver is presented. The major prerequisite is a converging sinusoidal flow pattern through a network of tubes with almost equal diameter. In this case the main hemodynamic resistance is located downstream at the outlet. Different geometric configurations (sphere, cylinder, and sections of these) are considered, and it is concluded that the precise shape of the microcirculatory unit is not crucial. The applicability in cirrhosis is considered in relation to a decreased diameter and number of the sinusoids in this condition. Estimated pressure profiles along the sinusoids indicate a steep downstream pressure fall in cirrhosis, implying that the spatial average of sinusoidal pressure is close to that of the inlet, i.e. portal pressure. Another prediction is an increased blood flow rate (flow rate per vessel) in the region near the outlet of the sinusoids.

AB - A model of pressure profile along the sinusoids in the liver is presented. The major prerequisite is a converging sinusoidal flow pattern through a network of tubes with almost equal diameter. In this case the main hemodynamic resistance is located downstream at the outlet. Different geometric configurations (sphere, cylinder, and sections of these) are considered, and it is concluded that the precise shape of the microcirculatory unit is not crucial. The applicability in cirrhosis is considered in relation to a decreased diameter and number of the sinusoids in this condition. Estimated pressure profiles along the sinusoids indicate a steep downstream pressure fall in cirrhosis, implying that the spatial average of sinusoidal pressure is close to that of the inlet, i.e. portal pressure. Another prediction is an increased blood flow rate (flow rate per vessel) in the region near the outlet of the sinusoids.

M3 - Journal article

C2 - 3367712

VL - 8

SP - 88

EP - 94

JO - Liver

JF - Liver

SN - 0106-9543

IS - 2

ER -

ID: 18698170