Predicting and monitoring of growth in children with short stature during the first year of growth hormone treatment
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Predicting and monitoring of growth in children with short stature during the first year of growth hormone treatment. / Mortensen, H B; Main, Katharina; Michaelsen, Kim F.; Kastrup, K W; Jørgensen, J T; Skakkebæk, Niels Erik.
In: Acta Paediatrica Scandinavica, Vol. 80, No. 12, 1991, p. 1150-1157.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Predicting and monitoring of growth in children with short stature during the first year of growth hormone treatment
AU - Mortensen, H B
AU - Main, Katharina
AU - Michaelsen, Kim F.
AU - Kastrup, K W
AU - Jørgensen, J T
AU - Skakkebæk, Niels Erik
PY - 1991
Y1 - 1991
N2 - Fifteen prepubertal short stature children (10 girls, 5 boys), mean age 9.6 years (range 5.2-12.7 years), with normal response to growth hormone stimulation tests (group A) or partial growth hormone deficiency (GHD) of idiopathic nature (group B) were included in a controlled longitudinal study for evaluation of predictive parameters for the long-term growth response after administration of biosynthetic human growth hormone (B-hGH). The average knee-heel length velocity for the first 3 months was significantly correlated to total body height velocity during the following 9 months (p < 0.0008). By contrast, this association could not be found for height velocity during the same period. The increase in serum values of alkaline phosphatase and insulin-like growth factor I (IGF-1) during the first month of treatment as not significantly correlated to height velocity during the first year. During one year of treatment with BhGH the mean height velocity for groups A and B increased from 4.4 cm/year (range 2.5-6.5) to 7.6 cm/year (range 4.7-10.6). Bone age advanced by 1.08±0.60 per chronological year. The ratio between total height and knee-heel length prior to treatment was 3.34±0.10 and after one year 3.33±0.10, suggesting a proportional linear growth. An inverse relationship was observed between the ratio and chronological age. In conclusion, early knee-heel measurement may be a useful non-invasive predictor of long-term linear growth in children during treatment with growth hormone, and the ratio of total height to lower leg length may be of importance in detecting dysproportional growth.
AB - Fifteen prepubertal short stature children (10 girls, 5 boys), mean age 9.6 years (range 5.2-12.7 years), with normal response to growth hormone stimulation tests (group A) or partial growth hormone deficiency (GHD) of idiopathic nature (group B) were included in a controlled longitudinal study for evaluation of predictive parameters for the long-term growth response after administration of biosynthetic human growth hormone (B-hGH). The average knee-heel length velocity for the first 3 months was significantly correlated to total body height velocity during the following 9 months (p < 0.0008). By contrast, this association could not be found for height velocity during the same period. The increase in serum values of alkaline phosphatase and insulin-like growth factor I (IGF-1) during the first month of treatment as not significantly correlated to height velocity during the first year. During one year of treatment with BhGH the mean height velocity for groups A and B increased from 4.4 cm/year (range 2.5-6.5) to 7.6 cm/year (range 4.7-10.6). Bone age advanced by 1.08±0.60 per chronological year. The ratio between total height and knee-heel length prior to treatment was 3.34±0.10 and after one year 3.33±0.10, suggesting a proportional linear growth. An inverse relationship was observed between the ratio and chronological age. In conclusion, early knee-heel measurement may be a useful non-invasive predictor of long-term linear growth in children during treatment with growth hormone, and the ratio of total height to lower leg length may be of importance in detecting dysproportional growth.
KW - Growth hormone treatment
KW - Growth response
KW - Short stature
UR - http://www.scopus.com/inward/record.url?scp=0026329865&partnerID=8YFLogxK
U2 - 10.1111/j.1651-2227.1991.tb11803.x
DO - 10.1111/j.1651-2227.1991.tb11803.x
M3 - Journal article
C2 - 1785287
AN - SCOPUS:0026329865
VL - 80
SP - 1150
EP - 1157
JO - Acta Paediatrica Scandinavica
JF - Acta Paediatrica Scandinavica
SN - 0001-656X
IS - 12
ER -
ID: 258035325