TY - JOUR

T1 - Practical algorithms for early diagnosis of heart failure and heart stress using NT-proBNP

T2 - A clinical consensus statement from the Heart Failure Association of the ESC

AU - Bayes-Genis, Antoni

AU - Docherty, Kieran F.

AU - Petrie, Mark C.

AU - Januzzi, James L.

AU - Mueller, Christian

AU - Anderson, Lisa

AU - Bozkurt, Biykem

AU - Butler, Javed

AU - Chioncel, Ovidiu

AU - Cleland, John G.F.

AU - Christodorescu, Ruxandra

AU - Del Prato, Stefano

AU - Gustafsson, Finn

AU - Lam, Carolyn S.P.

AU - Moura, Brenda

AU - Pop-Busui, Rodica

AU - Seferovic, Petar

AU - Volterrani, Maurizio

AU - Vaduganathan, Muthiah

AU - Metra, Marco

AU - Rosano, Giuseppe

N1 - Publisher Copyright: © 2023 European Society of Cardiology.

PY - 2023

Y1 - 2023

N2 - Diagnosing heart failure is often difficult due to the non-specific nature of symptoms, which can be caused by a range of medical conditions. Natriuretic peptides (NPs) have been recognized as important biomarkers for diagnosing heart failure. This document from the Heart Failure Association examines the practical uses of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in various clinical scenarios. The concentrations of NT-proBNP vary according to the patient profile and the clinical scenario, therefore values should be interpreted with caution to ensure appropriate diagnosis. Validated cut-points are provided to rule in or rule out acute heart failure in the emergency department and to diagnose de novo heart failure in the outpatient setting. We also coin the concept of ‘heart stress’ when NT-proBNP levels are elevated in an asymptomatic patient with risk factors for heart failure (i.e. diabetes, hypertension, coronary artery disease), underlying the development of cardiac dysfunction and further increased risk. We propose a simple acronym for healthcare professionals and patients, FIND-HF, which serves as a prompt to consider heart failure: Fatigue, Increased water accumulation, Natriuretic peptide testing, and Dyspnoea. Use of this acronym would enable the early diagnosis of heart failure. Overall, understanding and utilizing NT-proBNP levels will lead to earlier and more accurate diagnoses of heart failure ultimately improving patient outcomes and reducing healthcare costs.

AB - Diagnosing heart failure is often difficult due to the non-specific nature of symptoms, which can be caused by a range of medical conditions. Natriuretic peptides (NPs) have been recognized as important biomarkers for diagnosing heart failure. This document from the Heart Failure Association examines the practical uses of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in various clinical scenarios. The concentrations of NT-proBNP vary according to the patient profile and the clinical scenario, therefore values should be interpreted with caution to ensure appropriate diagnosis. Validated cut-points are provided to rule in or rule out acute heart failure in the emergency department and to diagnose de novo heart failure in the outpatient setting. We also coin the concept of ‘heart stress’ when NT-proBNP levels are elevated in an asymptomatic patient with risk factors for heart failure (i.e. diabetes, hypertension, coronary artery disease), underlying the development of cardiac dysfunction and further increased risk. We propose a simple acronym for healthcare professionals and patients, FIND-HF, which serves as a prompt to consider heart failure: Fatigue, Increased water accumulation, Natriuretic peptide testing, and Dyspnoea. Use of this acronym would enable the early diagnosis of heart failure. Overall, understanding and utilizing NT-proBNP levels will lead to earlier and more accurate diagnoses of heart failure ultimately improving patient outcomes and reducing healthcare costs.

KW - Heart failure

KW - Natriuretic peptides

KW - NT-proBNP

U2 - 10.1002/ejhf.3036

DO - 10.1002/ejhf.3036

M3 - Journal article

C2 - 37712339

AN - SCOPUS:85172245578

VL - 25

SP - 1891

EP - 1898

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1567-4215

IS - 11

ER -