Potential impact of diet on treatment effect from anti-TNF drugs in inflammatory bowel disease
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Potential impact of diet on treatment effect from anti-TNF drugs in inflammatory bowel disease. / Andersen, Vibeke; Hansen, Axel Kornerup; Heitmann, Berit Lilienthal.
In: Nutrients, Vol. 9, No. 3, 286, 03.2017.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Potential impact of diet on treatment effect from anti-TNF drugs in inflammatory bowel disease
AU - Andersen, Vibeke
AU - Hansen, Axel Kornerup
AU - Heitmann, Berit Lilienthal
PY - 2017/3
Y1 - 2017/3
N2 - We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73–4.31, p < 0.01, OR 2.93; 95% CI: 1.66–5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in prospective observational, animal and interventional studies are warranted.
AB - We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73–4.31, p < 0.01, OR 2.93; 95% CI: 1.66–5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in prospective observational, animal and interventional studies are warranted.
KW - Anti-TNF
KW - Chronic inflammatory diseases
KW - Diet
KW - Dietary pattern
KW - Epithelium-associated bacteria
KW - Fibre intake
KW - Food
KW - Lifestyle factors
KW - Meat intake
KW - Microbiome
KW - Mucin-degrading bacteria
KW - Mucosa associated bacteria
KW - Mucus
KW - Personalized medicine
KW - Sulphate-reducing bacteria
KW - Treatment response
KW - Treatment result
KW - Western style diet
U2 - 10.3390/nu9030286
DO - 10.3390/nu9030286
M3 - Review
C2 - 28294972
AN - SCOPUS:85015682944
VL - 9
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 286
ER -
ID: 186879685