Polysomnographic findings in craniopharyngioma patients
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Polysomnographic findings in craniopharyngioma patients. / Pickering, Line; Klose, Marianne; Feldt-Rasmussen, Ulla; Jennum, Poul.
In: Sleep and Breathing, Vol. 21, No. 4, 12.2017, p. 975-982.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Polysomnographic findings in craniopharyngioma patients
AU - Pickering, Line
AU - Klose, Marianne
AU - Feldt-Rasmussen, Ulla
AU - Jennum, Poul
PY - 2017/12
Y1 - 2017/12
N2 - PURPOSE: The purpose of this study is to evaluate whether damage to the hypothalamus due to craniopharyngioma or consequent surgery may involve the sleep-wake regulatory system, resulting in sleep disturbances and sleepiness.METHODS: Seven craniopharyngioma patients and 10 healthy controls were evaluated with sleep questionnaires including the Epworth Sleepiness Scale, polysomnography, and a multiple sleep latency test (MSLT). Five patients and eight controls had lumbar puncture performed to determine hypocretin-1 levels.RESULTS: Patients tended to feel sleepier than control individuals of the same age (p = 0.09). No subjects had symptoms of hypnagogic hallucinations, sleep paralyses, or cataplexies. Four patients and one control had periodic leg movements (PLMs). One patient had fragmented sleep pattern, rapid eye movement (REM) sleep without atonia, and PLMs. One patient had short sleep periods during the daytime. Four patients had fragmented sleep pattern. With the MSLT, four patients and two controls had mean sleep latency of < 8 min. One patient and three controls had sudden onset of REM sleep in 2/5 and 3/5 sleep periods, respectively. All subjects showed normal hypocretin-1 levels. Four patients had electrophysiological findings indicative of central hypersomnia including one patient meeting the criteria of narcolepsy.CONCLUSION: The sleep-wake regulatory system may be involved in craniopharyngioma patients.
AB - PURPOSE: The purpose of this study is to evaluate whether damage to the hypothalamus due to craniopharyngioma or consequent surgery may involve the sleep-wake regulatory system, resulting in sleep disturbances and sleepiness.METHODS: Seven craniopharyngioma patients and 10 healthy controls were evaluated with sleep questionnaires including the Epworth Sleepiness Scale, polysomnography, and a multiple sleep latency test (MSLT). Five patients and eight controls had lumbar puncture performed to determine hypocretin-1 levels.RESULTS: Patients tended to feel sleepier than control individuals of the same age (p = 0.09). No subjects had symptoms of hypnagogic hallucinations, sleep paralyses, or cataplexies. Four patients and one control had periodic leg movements (PLMs). One patient had fragmented sleep pattern, rapid eye movement (REM) sleep without atonia, and PLMs. One patient had short sleep periods during the daytime. Four patients had fragmented sleep pattern. With the MSLT, four patients and two controls had mean sleep latency of < 8 min. One patient and three controls had sudden onset of REM sleep in 2/5 and 3/5 sleep periods, respectively. All subjects showed normal hypocretin-1 levels. Four patients had electrophysiological findings indicative of central hypersomnia including one patient meeting the criteria of narcolepsy.CONCLUSION: The sleep-wake regulatory system may be involved in craniopharyngioma patients.
U2 - 10.1007/s11325-017-1574-6
DO - 10.1007/s11325-017-1574-6
M3 - Journal article
C2 - 28956242
VL - 21
SP - 975
EP - 982
JO - Sleep and Breathing
JF - Sleep and Breathing
SN - 1520-9512
IS - 4
ER -
ID: 195012671