Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis?

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Standard

Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis? / Johansen, J S; Møller, S; Price, P A; Bendtsen, F; Junge, J; Garbarsch, C; Henriksen, Jens Henrik Sahl.

In: Scandinavian Journal of Gastroenterology, Vol. 32, No. 6, 1997, p. 582-590.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Johansen, JS, Møller, S, Price, PA, Bendtsen, F, Junge, J, Garbarsch, C & Henriksen, JHS 1997, 'Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis?', Scandinavian Journal of Gastroenterology, vol. 32, no. 6, pp. 582-590.

APA

Johansen, J. S., Møller, S., Price, P. A., Bendtsen, F., Junge, J., Garbarsch, C., & Henriksen, J. H. S. (1997). Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis? Scandinavian Journal of Gastroenterology, 32(6), 582-590.

Vancouver

Johansen JS, Møller S, Price PA, Bendtsen F, Junge J, Garbarsch C et al. Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis? Scandinavian Journal of Gastroenterology. 1997;32(6):582-590.

Author

Johansen, J S ; Møller, S ; Price, P A ; Bendtsen, F ; Junge, J ; Garbarsch, C ; Henriksen, Jens Henrik Sahl. / Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis?. In: Scandinavian Journal of Gastroenterology. 1997 ; Vol. 32, No. 6. pp. 582-590.

Bibtex

@article{4b7df29074cb11dbbee902004c4f4f50,
title = "Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis?",
abstract = "BACKGROUND: YKL-40 (human cartilage glycoprotein-39, or 38-kDa heparin-binding glycoprotein) is a mammalian member of a protein family that includes bacterial chitinases. YKL-40 mRNA is expressed by human liver and may play a role in tissue remodelling. The aims were to assess whether circulating YKL-40 is released or extracted in the hepatosplanchnic system and to localize YKL-40 in liver tissue. METHODS: Plasma YKL-40 was determined by radioimmunoassay in 25 patients with liver diseases (alcoholic cirrhosis (n = 20), chronic active hepatitis (n = 2), cirrhosis of unknown aetiology (n = 2), and fatty liver (n = 1) and in 18 subjects with normal liver function during a haemodynamic investigation with catheterization of liver vein and the femoral artery. Immunohistochemical studies of the localization of YKL-40 in cryostal liver biopsy specimens were obtained from eight other patients with alcoholic liver disease. RESULTS: Plasma YKL-40 was significantly increased in patients with alcoholic cirrhosis (median, 523 micrograms/l; P < 0.001) compared with controls (106 micrograms/l), and plasma YKL-40 in the hepatic vein was higher (P < 0.01) than that of the artery in both the patients and controls, showing release of YKL-40 from the hepatosplanchnic area. The release rate of YKL-40 from the hepatosplanchnic area was higher in patients with liver disease than in controls (11.0 versus 2.1 micrograms/min, P < 0.05). Furthermore, the highest plasma YKL-40 levels were found in patients with a moderate or severe degree of liver fibrosis, and immunohistochemical studies showed positive staining for YKL-40 antigen in areas of the liver biopsy with fibrosis. CONCLUSIONS: The increased plasma YKL-40 in patients with alcoholic cirrhosis may reflect the remodelling of liver fibrosis.",
author = "Johansen, {J S} and S M{\o}ller and Price, {P A} and F Bendtsen and J Junge and C Garbarsch and Henriksen, {Jens Henrik Sahl}",
note = "Keywords: Biological Markers; Biopsy; Cartilage; Case-Control Studies; Female; Glycoproteins; Humans; Immunohistochemistry; Lectins; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases; Male; Middle Aged; Radioimmunoassay",
year = "1997",
language = "English",
volume = "32",
pages = "582--590",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Plasma YKL-40: a new potential marker of fibrosis in patients with alcoholic cirrhosis?

AU - Johansen, J S

AU - Møller, S

AU - Price, P A

AU - Bendtsen, F

AU - Junge, J

AU - Garbarsch, C

AU - Henriksen, Jens Henrik Sahl

N1 - Keywords: Biological Markers; Biopsy; Cartilage; Case-Control Studies; Female; Glycoproteins; Humans; Immunohistochemistry; Lectins; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases; Male; Middle Aged; Radioimmunoassay

PY - 1997

Y1 - 1997

N2 - BACKGROUND: YKL-40 (human cartilage glycoprotein-39, or 38-kDa heparin-binding glycoprotein) is a mammalian member of a protein family that includes bacterial chitinases. YKL-40 mRNA is expressed by human liver and may play a role in tissue remodelling. The aims were to assess whether circulating YKL-40 is released or extracted in the hepatosplanchnic system and to localize YKL-40 in liver tissue. METHODS: Plasma YKL-40 was determined by radioimmunoassay in 25 patients with liver diseases (alcoholic cirrhosis (n = 20), chronic active hepatitis (n = 2), cirrhosis of unknown aetiology (n = 2), and fatty liver (n = 1) and in 18 subjects with normal liver function during a haemodynamic investigation with catheterization of liver vein and the femoral artery. Immunohistochemical studies of the localization of YKL-40 in cryostal liver biopsy specimens were obtained from eight other patients with alcoholic liver disease. RESULTS: Plasma YKL-40 was significantly increased in patients with alcoholic cirrhosis (median, 523 micrograms/l; P < 0.001) compared with controls (106 micrograms/l), and plasma YKL-40 in the hepatic vein was higher (P < 0.01) than that of the artery in both the patients and controls, showing release of YKL-40 from the hepatosplanchnic area. The release rate of YKL-40 from the hepatosplanchnic area was higher in patients with liver disease than in controls (11.0 versus 2.1 micrograms/min, P < 0.05). Furthermore, the highest plasma YKL-40 levels were found in patients with a moderate or severe degree of liver fibrosis, and immunohistochemical studies showed positive staining for YKL-40 antigen in areas of the liver biopsy with fibrosis. CONCLUSIONS: The increased plasma YKL-40 in patients with alcoholic cirrhosis may reflect the remodelling of liver fibrosis.

AB - BACKGROUND: YKL-40 (human cartilage glycoprotein-39, or 38-kDa heparin-binding glycoprotein) is a mammalian member of a protein family that includes bacterial chitinases. YKL-40 mRNA is expressed by human liver and may play a role in tissue remodelling. The aims were to assess whether circulating YKL-40 is released or extracted in the hepatosplanchnic system and to localize YKL-40 in liver tissue. METHODS: Plasma YKL-40 was determined by radioimmunoassay in 25 patients with liver diseases (alcoholic cirrhosis (n = 20), chronic active hepatitis (n = 2), cirrhosis of unknown aetiology (n = 2), and fatty liver (n = 1) and in 18 subjects with normal liver function during a haemodynamic investigation with catheterization of liver vein and the femoral artery. Immunohistochemical studies of the localization of YKL-40 in cryostal liver biopsy specimens were obtained from eight other patients with alcoholic liver disease. RESULTS: Plasma YKL-40 was significantly increased in patients with alcoholic cirrhosis (median, 523 micrograms/l; P < 0.001) compared with controls (106 micrograms/l), and plasma YKL-40 in the hepatic vein was higher (P < 0.01) than that of the artery in both the patients and controls, showing release of YKL-40 from the hepatosplanchnic area. The release rate of YKL-40 from the hepatosplanchnic area was higher in patients with liver disease than in controls (11.0 versus 2.1 micrograms/min, P < 0.05). Furthermore, the highest plasma YKL-40 levels were found in patients with a moderate or severe degree of liver fibrosis, and immunohistochemical studies showed positive staining for YKL-40 antigen in areas of the liver biopsy with fibrosis. CONCLUSIONS: The increased plasma YKL-40 in patients with alcoholic cirrhosis may reflect the remodelling of liver fibrosis.

M3 - Journal article

C2 - 9200292

VL - 32

SP - 582

EP - 590

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 6

ER -

ID: 229565