Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial

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Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes : case-cohort study within the PREDIMED Trial. / Ruiz-Canela, Miguel; Guasch-Ferré, Marta; Toledo, Estefanía; Clish, Clary B.; Razquin, Cristina; Liang, Liming; Wang, Dong D.; Corella, Dolores; Estruch, Ramón; Hernáez, Álvaro; Yu, Edward; Gómez-Gracia, Enrique; Zheng, Yan; Arós, Fernando; Romaguera, Dora; Dennis, Courtney; Ros, Emilio; Lapetra, José; Serra-Majem, Lluis; Papandreou, Christopher; Portoles, Olga; Fitó, Montserrat; Salas-Salvadó, Jordi; Hu, Frank B.; Martínez-González, Miguel A.

In: Diabetologia, Vol. 61, No. 7, 2018, p. 1560-1571.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ruiz-Canela, M, Guasch-Ferré, M, Toledo, E, Clish, CB, Razquin, C, Liang, L, Wang, DD, Corella, D, Estruch, R, Hernáez, Á, Yu, E, Gómez-Gracia, E, Zheng, Y, Arós, F, Romaguera, D, Dennis, C, Ros, E, Lapetra, J, Serra-Majem, L, Papandreou, C, Portoles, O, Fitó, M, Salas-Salvadó, J, Hu, FB & Martínez-González, MA 2018, 'Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial', Diabetologia, vol. 61, no. 7, pp. 1560-1571. https://doi.org/10.1007/s00125-018-4611-5

APA

Ruiz-Canela, M., Guasch-Ferré, M., Toledo, E., Clish, C. B., Razquin, C., Liang, L., Wang, D. D., Corella, D., Estruch, R., Hernáez, Á., Yu, E., Gómez-Gracia, E., Zheng, Y., Arós, F., Romaguera, D., Dennis, C., Ros, E., Lapetra, J., Serra-Majem, L., ... Martínez-González, M. A. (2018). Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial. Diabetologia, 61(7), 1560-1571. https://doi.org/10.1007/s00125-018-4611-5

Vancouver

Ruiz-Canela M, Guasch-Ferré M, Toledo E, Clish CB, Razquin C, Liang L et al. Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial. Diabetologia. 2018;61(7):1560-1571. https://doi.org/10.1007/s00125-018-4611-5

Author

Ruiz-Canela, Miguel ; Guasch-Ferré, Marta ; Toledo, Estefanía ; Clish, Clary B. ; Razquin, Cristina ; Liang, Liming ; Wang, Dong D. ; Corella, Dolores ; Estruch, Ramón ; Hernáez, Álvaro ; Yu, Edward ; Gómez-Gracia, Enrique ; Zheng, Yan ; Arós, Fernando ; Romaguera, Dora ; Dennis, Courtney ; Ros, Emilio ; Lapetra, José ; Serra-Majem, Lluis ; Papandreou, Christopher ; Portoles, Olga ; Fitó, Montserrat ; Salas-Salvadó, Jordi ; Hu, Frank B. ; Martínez-González, Miguel A. / Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes : case-cohort study within the PREDIMED Trial. In: Diabetologia. 2018 ; Vol. 61, No. 7. pp. 1560-1571.

Bibtex

@article{d51a725ad3744fd19734faef0296751a,
title = "Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial",
abstract = "Aims/hypothesis: Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods: We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvenci{\'o}n con DIeta MEDiterr{\'a}nea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results: Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p = 0.005 vs the control group). Conclusions/interpretation: Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 (www.controlled-trials.com).",
keywords = "Aromatic amino acids, Branched-chain amino acids, Mediterranean diet, Type 2 diabetes",
author = "Miguel Ruiz-Canela and Marta Guasch-Ferr{\'e} and Estefan{\'i}a Toledo and Clish, {Clary B.} and Cristina Razquin and Liming Liang and Wang, {Dong D.} and Dolores Corella and Ram{\'o}n Estruch and {\'A}lvaro Hern{\'a}ez and Edward Yu and Enrique G{\'o}mez-Gracia and Yan Zheng and Fernando Ar{\'o}s and Dora Romaguera and Courtney Dennis and Emilio Ros and Jos{\'e} Lapetra and Lluis Serra-Majem and Christopher Papandreou and Olga Portoles and Montserrat Fit{\'o} and Jordi Salas-Salvad{\'o} and Hu, {Frank B.} and Mart{\'i}nez-Gonz{\'a}lez, {Miguel A.}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2018",
doi = "10.1007/s00125-018-4611-5",
language = "English",
volume = "61",
pages = "1560--1571",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes

T2 - case-cohort study within the PREDIMED Trial

AU - Ruiz-Canela, Miguel

AU - Guasch-Ferré, Marta

AU - Toledo, Estefanía

AU - Clish, Clary B.

AU - Razquin, Cristina

AU - Liang, Liming

AU - Wang, Dong D.

AU - Corella, Dolores

AU - Estruch, Ramón

AU - Hernáez, Álvaro

AU - Yu, Edward

AU - Gómez-Gracia, Enrique

AU - Zheng, Yan

AU - Arós, Fernando

AU - Romaguera, Dora

AU - Dennis, Courtney

AU - Ros, Emilio

AU - Lapetra, José

AU - Serra-Majem, Lluis

AU - Papandreou, Christopher

AU - Portoles, Olga

AU - Fitó, Montserrat

AU - Salas-Salvadó, Jordi

AU - Hu, Frank B.

AU - Martínez-González, Miguel A.

N1 - Publisher Copyright: © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2018

Y1 - 2018

N2 - Aims/hypothesis: Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods: We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results: Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p = 0.005 vs the control group). Conclusions/interpretation: Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 (www.controlled-trials.com).

AB - Aims/hypothesis: Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods: We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvención con DIeta MEDiterránea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n = 273), a MedDiet+nuts (n = 324) or a control diet (n = 295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results: Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend = 0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD = 1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p = 0.005 vs the control group). Conclusions/interpretation: Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 (www.controlled-trials.com).

KW - Aromatic amino acids

KW - Branched-chain amino acids

KW - Mediterranean diet

KW - Type 2 diabetes

U2 - 10.1007/s00125-018-4611-5

DO - 10.1007/s00125-018-4611-5

M3 - Journal article

C2 - 29663011

AN - SCOPUS:85045441217

VL - 61

SP - 1560

EP - 1571

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 7

ER -

ID: 358106341