Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Physician-defined severe toxicities occurring during and after cancer treatment : Modified consensus definitions and clinical applicability in the evaluation of cancer treatment. / Nielsen, Camilla Grud; Thomsen, Birthe Lykke; Als-Nielsen, Bodil; Conyers, Rachel; Jeha, Sima; Mateos, Marion K.; Mlynarski, Wojciech; Pieters, Rob; Rathe, Mathias; Schmiegelow, Kjeld; Andres-Jensen, Liv; Ponte Legno Severe Toxicity.

In: Frontiers in Pediatrics, Vol. 11, 1155449, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, CG, Thomsen, BL, Als-Nielsen, B, Conyers, R, Jeha, S, Mateos, MK, Mlynarski, W, Pieters, R, Rathe, M, Schmiegelow, K, Andres-Jensen, L & Ponte Legno Severe Toxicity 2023, 'Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment', Frontiers in Pediatrics, vol. 11, 1155449. https://doi.org/10.3389/fped.2023.1155449

APA

Nielsen, C. G., Thomsen, B. L., Als-Nielsen, B., Conyers, R., Jeha, S., Mateos, M. K., Mlynarski, W., Pieters, R., Rathe, M., Schmiegelow, K., Andres-Jensen, L., & Ponte Legno Severe Toxicity (2023). Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment. Frontiers in Pediatrics, 11, [1155449]. https://doi.org/10.3389/fped.2023.1155449

Vancouver

Nielsen CG, Thomsen BL, Als-Nielsen B, Conyers R, Jeha S, Mateos MK et al. Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment. Frontiers in Pediatrics. 2023;11. 1155449. https://doi.org/10.3389/fped.2023.1155449

Author

Nielsen, Camilla Grud ; Thomsen, Birthe Lykke ; Als-Nielsen, Bodil ; Conyers, Rachel ; Jeha, Sima ; Mateos, Marion K. ; Mlynarski, Wojciech ; Pieters, Rob ; Rathe, Mathias ; Schmiegelow, Kjeld ; Andres-Jensen, Liv ; Ponte Legno Severe Toxicity. / Physician-defined severe toxicities occurring during and after cancer treatment : Modified consensus definitions and clinical applicability in the evaluation of cancer treatment. In: Frontiers in Pediatrics. 2023 ; Vol. 11.

Bibtex

@article{ac5c3204b3484281b1edfaf62fecdd1f,
title = "Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment",
abstract = "Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.",
keywords = "cancer treatment, toxicities, childhood cancer, long-term, severe-toxicity-free-survival, COMPETING RISKS, CHILDHOOD, BURDEN",
author = "Nielsen, {Camilla Grud} and Thomsen, {Birthe Lykke} and Bodil Als-Nielsen and Rachel Conyers and Sima Jeha and Mateos, {Marion K.} and Wojciech Mlynarski and Rob Pieters and Mathias Rathe and Kjeld Schmiegelow and Liv Andres-Jensen and {Ponte Legno Severe Toxicity}",
year = "2023",
doi = "10.3389/fped.2023.1155449",
language = "English",
volume = "11",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - Physician-defined severe toxicities occurring during and after cancer treatment

T2 - Modified consensus definitions and clinical applicability in the evaluation of cancer treatment

AU - Nielsen, Camilla Grud

AU - Thomsen, Birthe Lykke

AU - Als-Nielsen, Bodil

AU - Conyers, Rachel

AU - Jeha, Sima

AU - Mateos, Marion K.

AU - Mlynarski, Wojciech

AU - Pieters, Rob

AU - Rathe, Mathias

AU - Schmiegelow, Kjeld

AU - Andres-Jensen, Liv

AU - Ponte Legno Severe Toxicity

PY - 2023

Y1 - 2023

N2 - Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.

AB - Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.

KW - cancer treatment

KW - toxicities

KW - childhood cancer

KW - long-term

KW - severe-toxicity-free-survival

KW - COMPETING RISKS

KW - CHILDHOOD

KW - BURDEN

U2 - 10.3389/fped.2023.1155449

DO - 10.3389/fped.2023.1155449

M3 - Journal article

C2 - 37181427

VL - 11

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

SN - 2296-2360

M1 - 1155449

ER -

ID: 347864893