Physical activity level is impaired and diet dependent in preterm newborn pigs
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Physical activity level is impaired and diet dependent in preterm newborn pigs. / Cao, Muqing; Andersen, Anders Daniel; Van Ginneken, Chris; Shen, René Liang; Petersen, Stine Ostenfeldt; Thymann, Thomas; Jing, Jin; Sangild, Per Torp.
In: Pediatric Research, Vol. 78, No. 2, 2015, p. 137-144.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Physical activity level is impaired and diet dependent in preterm newborn pigs
AU - Cao, Muqing
AU - Andersen, Anders Daniel
AU - Van Ginneken, Chris
AU - Shen, René Liang
AU - Petersen, Stine Ostenfeldt
AU - Thymann, Thomas
AU - Jing, Jin
AU - Sangild, Per Torp
N1 - CURIS 2015 NEXS 193
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Preterm infants show delayed development of motor function after birth. This may relate to functional immaturity of many organs, including the gut and brain. Using pigs as model for preterm infants, we hypothesized that early initiation of enteral feeding stimulates both gut growth and neonatal physical activity.METHODS: In experiment 1, preterm and term pigs were fed parenteral nutrition (PN) or PN plus bovine colostrum (BC, 16-64 ml/kg/d enterally) for 5 d. In experiment 2, preterm pigs were fed PN+BC or PN+formula for 5 d. In experiment 3, preterm pigs were fed BC, formula, or human milk (HM) for 10 d. Incubator home cage activity (HCA) was quantified by continuous camera recordings.RESULTS: Preterm birth was associated with reduced intestinal weight and HCA (experiment 1), and BC or formula supplementation increased intestinal weights and HCA (experiments 1+2). Enteral BC and HM feeding increased HCA, intestinal weights, and necrotizing enteritis resistance, relative to formula (experiment 3).CONCLUSION: Preterm pigs show decreased physical activity, and the first enteral feeds diet dependently stimulate both gut growth and physical activity. The effects may arise from maturation of digestive, metabolic, and neurological functions, including gut serotonin production, by the first enteral feeds and milk bioactive factors.Pediatric Research (2015); doi:10.1038/pr.2015.73.
AB - BACKGROUND: Preterm infants show delayed development of motor function after birth. This may relate to functional immaturity of many organs, including the gut and brain. Using pigs as model for preterm infants, we hypothesized that early initiation of enteral feeding stimulates both gut growth and neonatal physical activity.METHODS: In experiment 1, preterm and term pigs were fed parenteral nutrition (PN) or PN plus bovine colostrum (BC, 16-64 ml/kg/d enterally) for 5 d. In experiment 2, preterm pigs were fed PN+BC or PN+formula for 5 d. In experiment 3, preterm pigs were fed BC, formula, or human milk (HM) for 10 d. Incubator home cage activity (HCA) was quantified by continuous camera recordings.RESULTS: Preterm birth was associated with reduced intestinal weight and HCA (experiment 1), and BC or formula supplementation increased intestinal weights and HCA (experiments 1+2). Enteral BC and HM feeding increased HCA, intestinal weights, and necrotizing enteritis resistance, relative to formula (experiment 3).CONCLUSION: Preterm pigs show decreased physical activity, and the first enteral feeds diet dependently stimulate both gut growth and physical activity. The effects may arise from maturation of digestive, metabolic, and neurological functions, including gut serotonin production, by the first enteral feeds and milk bioactive factors.Pediatric Research (2015); doi:10.1038/pr.2015.73.
U2 - 10.1038/pr.2015.73
DO - 10.1038/pr.2015.73
M3 - Journal article
C2 - 25918838
VL - 78
SP - 137
EP - 144
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 2
ER -
ID: 138187876