PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
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PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites. / Andersen, Gitte; Wegner, Lise; Jensen, Dorit Packert; Glümer, Charlotte; Tarnow, Lise; Drivsholm, Thomas; Poulsen, Pernille; Hansen, Sara Kristine; Nielsen, Eva-Maria Damsgaard; Ek, Jakob; Mouritzen, Peter; Vaag, Allan; Parving, Hans-Henrik; Borch-Johnsen, Knut; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf.
In: Hypertension, Vol. 45, No. 4, 01.04.2005, p. 565-70.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites
AU - Andersen, Gitte
AU - Wegner, Lise
AU - Jensen, Dorit Packert
AU - Glümer, Charlotte
AU - Tarnow, Lise
AU - Drivsholm, Thomas
AU - Poulsen, Pernille
AU - Hansen, Sara Kristine
AU - Nielsen, Eva-Maria Damsgaard
AU - Ek, Jakob
AU - Mouritzen, Peter
AU - Vaag, Allan
AU - Parving, Hans-Henrik
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Hansen, Torben
AU - Pedersen, Oluf
PY - 2005/4/1
Y1 - 2005/4/1
N2 - PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.
AB - PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.
KW - Adult
KW - Aged
KW - Blood Pressure
KW - Denmark
KW - European Continental Ancestry Group
KW - Female
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Glycine
KW - Heat-Shock Proteins
KW - Humans
KW - Hypertension
KW - Male
KW - Middle Aged
KW - Polymorphism, Genetic
KW - Polymorphism, Restriction Fragment Length
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Risk
KW - Serine
KW - Sex Characteristics
KW - Transcription Factors
U2 - 10.1161/01.HYP.0000158946.53289.24
DO - 10.1161/01.HYP.0000158946.53289.24
M3 - Journal article
C2 - 15738346
VL - 45
SP - 565
EP - 570
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 4
ER -
ID: 33030458