Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. / Adlercreutz, Emma H; Clinical Sciences, Malmö, Lund University, Department; Merlo, Juan; uni, lund.

In: Acta paediatrica (Oslo, Norway : 1992), Vol. 104, No. 2, 02.2015, p. 178-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Adlercreutz, EH, Clinical Sciences, Malmö, Lund University, D, Merlo, J & uni, L 2015, 'Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease', Acta paediatrica (Oslo, Norway : 1992), vol. 104, no. 2, pp. 178-84. https://doi.org/10.1111/apa.12836

APA

Adlercreutz, E. H., Clinical Sciences, Malmö, Lund University, D., Merlo, J., & uni, L. (2015). Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. Acta paediatrica (Oslo, Norway : 1992), 104(2), 178-84. https://doi.org/10.1111/apa.12836

Vancouver

Adlercreutz EH, Clinical Sciences, Malmö, Lund University D, Merlo J, uni L. Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. Acta paediatrica (Oslo, Norway : 1992). 2015 Feb;104(2):178-84. https://doi.org/10.1111/apa.12836

Author

Adlercreutz, Emma H ; Clinical Sciences, Malmö, Lund University, Department ; Merlo, Juan ; uni, lund. / Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. In: Acta paediatrica (Oslo, Norway : 1992). 2015 ; Vol. 104, No. 2. pp. 178-84.

Bibtex

@article{5df62ca0e20e405e974ae48fc5fda2f5,
title = "Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease",
abstract = "AIM: This study investigated whether perinatal factors influenced the risk of a double diagnosis of type 1 diabetes and coeliac disease.METHODS: We used multinomial logistic regression models to study the associations between perinatal factors, gender, mode of delivery, season of birth and the risk of type 1 diabetes, coeliac disease or both, in Swedish-born singleton children.RESULTS: We found that 4327 of the 768 395 children (0.6%) had been diagnosed with type 1 diabetes, 3817 (0.5%) had been diagnosed with coeliac disease and 191 (0.02%) were affected by both diseases. If the children already had type 1 diabetes (n = 4518), the absolute risk of being affected by coeliac disease increased to 4.2% (n = 191). Children with both type 1 diabetes and coeliac disease were more likely to be female (OR = 1.48, 95% CI = 1.01-1.97), delivered by Caesarean section (OR = 1.60, 95% CI = 1.07-2.39), have native-born Swedish mothers (OR = 4.84, 95% CI = 1.96-11.97) or be born during the summer months (OR = 1.43, 95% CI = 1.07-1.92).CONCLUSION: The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.",
keywords = "Adult, Celiac Disease/complications, Cesarean Section/adverse effects, Child, Preschool, Diabetes Mellitus, Type 1/complications, Female, Humans, Infant, Infant, Newborn, Logistic Models, Male, Pregnancy, Retrospective Studies, Risk Factors, Seasons, Sweden/epidemiology, Young Adult",
author = "Adlercreutz, {Emma H} and {Clinical Sciences, Malm{\"o}, Lund University}, Department and Juan Merlo and lund uni",
note = "{\textcopyright}2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.",
year = "2015",
month = feb,
doi = "10.1111/apa.12836",
language = "English",
volume = "104",
pages = "178--84",
journal = "Acta Paediatrica",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease

AU - Adlercreutz, Emma H

AU - Clinical Sciences, Malmö, Lund University, Department

AU - Merlo, Juan

AU - uni, lund

N1 - ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

PY - 2015/2

Y1 - 2015/2

N2 - AIM: This study investigated whether perinatal factors influenced the risk of a double diagnosis of type 1 diabetes and coeliac disease.METHODS: We used multinomial logistic regression models to study the associations between perinatal factors, gender, mode of delivery, season of birth and the risk of type 1 diabetes, coeliac disease or both, in Swedish-born singleton children.RESULTS: We found that 4327 of the 768 395 children (0.6%) had been diagnosed with type 1 diabetes, 3817 (0.5%) had been diagnosed with coeliac disease and 191 (0.02%) were affected by both diseases. If the children already had type 1 diabetes (n = 4518), the absolute risk of being affected by coeliac disease increased to 4.2% (n = 191). Children with both type 1 diabetes and coeliac disease were more likely to be female (OR = 1.48, 95% CI = 1.01-1.97), delivered by Caesarean section (OR = 1.60, 95% CI = 1.07-2.39), have native-born Swedish mothers (OR = 4.84, 95% CI = 1.96-11.97) or be born during the summer months (OR = 1.43, 95% CI = 1.07-1.92).CONCLUSION: The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.

AB - AIM: This study investigated whether perinatal factors influenced the risk of a double diagnosis of type 1 diabetes and coeliac disease.METHODS: We used multinomial logistic regression models to study the associations between perinatal factors, gender, mode of delivery, season of birth and the risk of type 1 diabetes, coeliac disease or both, in Swedish-born singleton children.RESULTS: We found that 4327 of the 768 395 children (0.6%) had been diagnosed with type 1 diabetes, 3817 (0.5%) had been diagnosed with coeliac disease and 191 (0.02%) were affected by both diseases. If the children already had type 1 diabetes (n = 4518), the absolute risk of being affected by coeliac disease increased to 4.2% (n = 191). Children with both type 1 diabetes and coeliac disease were more likely to be female (OR = 1.48, 95% CI = 1.01-1.97), delivered by Caesarean section (OR = 1.60, 95% CI = 1.07-2.39), have native-born Swedish mothers (OR = 4.84, 95% CI = 1.96-11.97) or be born during the summer months (OR = 1.43, 95% CI = 1.07-1.92).CONCLUSION: The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.

KW - Adult

KW - Celiac Disease/complications

KW - Cesarean Section/adverse effects

KW - Child, Preschool

KW - Diabetes Mellitus, Type 1/complications

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Logistic Models

KW - Male

KW - Pregnancy

KW - Retrospective Studies

KW - Risk Factors

KW - Seasons

KW - Sweden/epidemiology

KW - Young Adult

U2 - 10.1111/apa.12836

DO - 10.1111/apa.12836

M3 - Journal article

C2 - 25346455

VL - 104

SP - 178

EP - 184

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 2

ER -

ID: 364796030