Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir
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Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. / Knudsen, Andreas D; Krebs-Demmer, Lisanne; Bjørge, Natascha I D; Elming, Marie B; Gelpi, Marco; Sigvardsen, Per E; Lebech, Anne-Mette; Fuchs, Andreas; Kühl, Jørgen T; Køber, Lars; Lundgren, Jens; Nordestgaard, Børge G; Kofoed, Klaus F; Nielsen, Susanne D.
In: The Journal of Infectious Diseases, Vol. 222, No. 1, 2020, p. 54-61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir
AU - Knudsen, Andreas D
AU - Krebs-Demmer, Lisanne
AU - Bjørge, Natascha I D
AU - Elming, Marie B
AU - Gelpi, Marco
AU - Sigvardsen, Per E
AU - Lebech, Anne-Mette
AU - Fuchs, Andreas
AU - Kühl, Jørgen T
AU - Køber, Lars
AU - Lundgren, Jens
AU - Nordestgaard, Børge G
AU - Kofoed, Klaus F
AU - Nielsen, Susanne D
N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors.METHODS: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography.RESULTS: A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10-23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, -6 to -25; P = .002) lower pericardial adipose tissue volume.CONCLUSIONS: Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population.
AB - BACKGROUND: Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors.METHODS: Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography.RESULTS: A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10-23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, -6 to -25; P = .002) lower pericardial adipose tissue volume.CONCLUSIONS: Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population.
KW - Adipose Tissue/drug effects
KW - Adult
KW - Anti-HIV Agents/adverse effects
KW - Cardiovascular Diseases/chemically induced
KW - Denmark
KW - Didanosine/adverse effects
KW - Female
KW - HIV Infections/drug therapy
KW - HIV Protease Inhibitors/therapeutic use
KW - Healthy Volunteers
KW - Humans
KW - Indinavir/adverse effects
KW - Male
KW - Middle Aged
KW - Pericardium/physiopathology
KW - Risk Factors
KW - Stavudine/adverse effects
KW - Viral Load
U2 - 10.1093/infdis/jiaa057
DO - 10.1093/infdis/jiaa057
M3 - Journal article
C2 - 32027374
VL - 222
SP - 54
EP - 61
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -
ID: 259515094