Percutaneous coronary intervention in calcified stenoses: a protocol for a systematic review with meta-analysis, trial sequential analysis and network meta-analysis
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Percutaneous coronary intervention in calcified stenoses : a protocol for a systematic review with meta-analysis, trial sequential analysis and network meta-analysis. / Kristensen, Andreas Torp; Jakobsen, Janus C.; Olsen, Niels Thue.
In: BMJ Open, Vol. 12, No. 9, e063884, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Percutaneous coronary intervention in calcified stenoses
T2 - a protocol for a systematic review with meta-analysis, trial sequential analysis and network meta-analysis
AU - Kristensen, Andreas Torp
AU - Jakobsen, Janus C.
AU - Olsen, Niels Thue
N1 - Publisher Copyright: © 2022 BMJ Publishing Group. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Introduction Severely calcified coronary stenoses are difficult to treat with percutaneous coronary interventions. The presence of severe calcifications complicates lesion preparation, advancement of stents and achievement of full stent expansion. Intervention in these lesions is associated with an increased risk of complications and procedural failure compared with treatment of less calcified lesions. Due to the high burden of comorbidity, patients with severely calcified lesions are often excluded from interventional trials, and there is little evidence on how to treat these patients. Methods and analysis We will conduct a systematic review of randomised trials enrolling patients with calcified coronary artery disease undergoing percutaneous coronary intervention. We will investigate any percutaneous treatment option including any lesion preparation, stenting or postdilatation technique. We will search The Cochrane Central Register of Controlled Trials, Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Health Sciences Literature, Science Citation Index Expanded, and Excerpta Medica database for studies from inception to 31 October 2022. The coprimary outcome is all-cause mortality and serious adverse events. If appropriate, we will conduct meta-analysis, trial sequential analysis and network meta-analysis. Ethics and dissemination No ethics approval is required for this study. The results will be published in a peer-reviewed journal in this field. PROSPERO registration number CRD42021226034.
AB - Introduction Severely calcified coronary stenoses are difficult to treat with percutaneous coronary interventions. The presence of severe calcifications complicates lesion preparation, advancement of stents and achievement of full stent expansion. Intervention in these lesions is associated with an increased risk of complications and procedural failure compared with treatment of less calcified lesions. Due to the high burden of comorbidity, patients with severely calcified lesions are often excluded from interventional trials, and there is little evidence on how to treat these patients. Methods and analysis We will conduct a systematic review of randomised trials enrolling patients with calcified coronary artery disease undergoing percutaneous coronary intervention. We will investigate any percutaneous treatment option including any lesion preparation, stenting or postdilatation technique. We will search The Cochrane Central Register of Controlled Trials, Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Health Sciences Literature, Science Citation Index Expanded, and Excerpta Medica database for studies from inception to 31 October 2022. The coprimary outcome is all-cause mortality and serious adverse events. If appropriate, we will conduct meta-analysis, trial sequential analysis and network meta-analysis. Ethics and dissemination No ethics approval is required for this study. The results will be published in a peer-reviewed journal in this field. PROSPERO registration number CRD42021226034.
KW - Coronary intervention
KW - Ischaemic heart disease
KW - Myocardial infarction
U2 - 10.1136/bmjopen-2022-063884
DO - 10.1136/bmjopen-2022-063884
M3 - Review
C2 - 36691161
AN - SCOPUS:85138513736
VL - 12
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 9
M1 - e063884
ER -
ID: 327692965