Pedunculopontine Chx10 + neurons control global motor arrest in mice.
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Pedunculopontine Chx10 + neurons control global motor arrest in mice. / Goñi-Erro, Haizea; Selvan, Raghavendra; Caggiano, Vittorio; Leiras, Roberto; Kiehn, Ole.
In: Nature Neuroscience, Vol. 26, 2023, p. 1516–1528.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pedunculopontine Chx10 + neurons control global motor arrest in mice.
AU - Goñi-Erro, Haizea
AU - Selvan, Raghavendra
AU - Caggiano, Vittorio
AU - Leiras, Roberto
AU - Kiehn, Ole
N1 - Author Correction: https://www.nature.com/articles/s41593-023-01422-4
PY - 2023
Y1 - 2023
N2 - Arrest of ongoing movements is an integral part of executing motor programs. Behavioral arrest may happen upon termination of a variety of goal-directed movements or as a global motor arrest either in the context of fear or in response to salient environmental cues. The neuronal circuits that bridge with the executive motor circuits to implement a global motor arrest are poorly understood. We report the discovery that the activation of glutamatergic Chx10-derived neurons in the pedunculopontine nucleus (PPN) in mice arrests all ongoing movements while simultaneously causing apnea and bradycardia. This global motor arrest has a pause-and-play pattern with an instantaneous interruption of movement followed by a short-latency continuation from where it was paused. Mice naturally perform arrest bouts with the same combination of motor and autonomic features. The Chx10-PPN-evoked arrest is different to ventrolateral periaqueductal gray-induced freezing. Our study defines a motor command that induces a global motor arrest, which may be recruited in response to salient environmental cues to allow for a preparatory or arousal state, and identifies a locomotor-opposing role for rostrally biased glutamatergic neurons in the PPN.
AB - Arrest of ongoing movements is an integral part of executing motor programs. Behavioral arrest may happen upon termination of a variety of goal-directed movements or as a global motor arrest either in the context of fear or in response to salient environmental cues. The neuronal circuits that bridge with the executive motor circuits to implement a global motor arrest are poorly understood. We report the discovery that the activation of glutamatergic Chx10-derived neurons in the pedunculopontine nucleus (PPN) in mice arrests all ongoing movements while simultaneously causing apnea and bradycardia. This global motor arrest has a pause-and-play pattern with an instantaneous interruption of movement followed by a short-latency continuation from where it was paused. Mice naturally perform arrest bouts with the same combination of motor and autonomic features. The Chx10-PPN-evoked arrest is different to ventrolateral periaqueductal gray-induced freezing. Our study defines a motor command that induces a global motor arrest, which may be recruited in response to salient environmental cues to allow for a preparatory or arousal state, and identifies a locomotor-opposing role for rostrally biased glutamatergic neurons in the PPN.
U2 - 10.1038/s41593-023-01396-3
DO - 10.1038/s41593-023-01396-3
M3 - Journal article
C2 - 37501003
VL - 26
SP - 1516
EP - 1528
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
ER -
ID: 361392528