Pathogenesis of hepatic steatosis and fibrosis: Role of leptin
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver abnormalities, ranging from simple steatosis, to steatohepatitis and cirrhosis, in the absence of “excessive” alcohol consumption or any other identifiable cause(s) for liver disease [1]. Histologically, NAFLD can be categorized into: (1) simple steatosis in the absence of hepatocellular injury (nonalcoholic fatty liver, NAFL); and (2) steatohepatitis (nonalcoholic steatohepatitis, NASH), characterized by the presence of steatosis and inflammation with hepatic injury (ballooning), with or without fibrosis [1]. NASH can progress to cirrhosis, liver failure, and rarely liver cancer, whereas the progression to more severe forms of liver disease is minimal in patients with NAFL. Steatosis is the hallmark of NAFL and NAFLD and can be defined chemically, when intrahepatic triglyceride (IHTG) content exceeds 5 % of liver volume or liver weight [2], histologically, when 5 % of hepatocytes contain visible intracellular triglyceride [3], and radiologically, by using magnetic resonance spectroscopy (MRS) [4]. The results from one study in subjects who were considered to be at low-risk for NAFLD (i.e., normal weight, normal fasting serum glucose and alanine aminotransferase concentrations, and absence of diabetes) indicate an upper “normal” amount of IHTG of 5.6 % of liver volume, which represented the 95th percentile in this population [5]. Data from another study found the 95th percentile for IHTG content was 3 % in young lean subjects with normal oral glucose tolerance [6].
Original language | English |
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Title of host publication | Leptin : Regulation and Clinical Applications |
Editors | Sam Dagogo-Jack |
Number of pages | 13 |
Place of Publication | Memphis, TN |
Publisher | Springer |
Publication date | 2015 |
Pages | 89-101 |
Chapter | 8 |
ISBN (Print) | 9783319099149 |
ISBN (Electronic) | 9783319099156 |
DOIs | |
Publication status | Published - 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:
© Springer International Publishing Switzerland 2015.
Links
- https://rdcu.be/c1J3R
Final published version
ID: 302380559