Particulate matter air pollution components and risk for lung cancer
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Particulate matter air pollution components and risk for lung cancer. / Raaschou-Nielsen, O; Beelen, R; Wang, M.; Hoek, G; Andersen, Z J; Hoffmann, B; Stafoggia, M; Samoli, E; Weinmayr, G; Dimakopoulou, K; Nieuwenhuijsen, M; Xun, W W; Fischer, P; Eriksen, K T; Sørensen, M; Tjønneland, A; Ricceri, F; de Hoogh, K; Key, T; Eeftens, M; Peeters, P H; Bueno-de-Mesquita, H B; Meliefste, K; Oftedal, B; Schwarze, P E; Nafstad, P; Galassi, C; Migliore, E; Ranzi, A; Cesaroni, G; Badaloni, C; Forastiere, F; Penell, J; De Faire, U; Korek, M; Pedersen, N; Östenson, C-G; Pershagen, G; Fratiglioni, L; Concin, H; Nagel, G; Jaensch, A; Ineichen, A; Naccarati, A; Katsoulis, M; Trichpoulou, A; Keuken, M; Jedynska, A; Kooter, I M; Kukkonen, J; Brunekreef, B; Sokhi, R S; Katsouyanni, K; Vineis, P.
In: Environment International, Vol. 87, 02.2016, p. 66-73.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Particulate matter air pollution components and risk for lung cancer
AU - Raaschou-Nielsen, O
AU - Beelen, R
AU - Wang, M.
AU - Hoek, G
AU - Andersen, Z J
AU - Hoffmann, B
AU - Stafoggia, M
AU - Samoli, E
AU - Weinmayr, G
AU - Dimakopoulou, K
AU - Nieuwenhuijsen, M
AU - Xun, W W
AU - Fischer, P
AU - Eriksen, K T
AU - Sørensen, M
AU - Tjønneland, A
AU - Ricceri, F
AU - de Hoogh, K
AU - Key, T
AU - Eeftens, M
AU - Peeters, P H
AU - Bueno-de-Mesquita, H B
AU - Meliefste, K
AU - Oftedal, B
AU - Schwarze, P E
AU - Nafstad, P
AU - Galassi, C
AU - Migliore, E
AU - Ranzi, A
AU - Cesaroni, G
AU - Badaloni, C
AU - Forastiere, F
AU - Penell, J
AU - De Faire, U
AU - Korek, M
AU - Pedersen, N
AU - Östenson, C-G
AU - Pershagen, G
AU - Fratiglioni, L
AU - Concin, H
AU - Nagel, G
AU - Jaensch, A
AU - Ineichen, A
AU - Naccarati, A
AU - Katsoulis, M
AU - Trichpoulou, A
AU - Keuken, M
AU - Jedynska, A
AU - Kooter, I M
AU - Kukkonen, J
AU - Brunekreef, B
AU - Sokhi, R S
AU - Katsouyanni, K
AU - Vineis, P
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.
AB - BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.RESULTS: The 245,782 cohort members contributed 3,229,220person-years at risk. During follow-up (mean, 13.1years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S.CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.
U2 - 10.1016/j.envint.2015.11.007
DO - 10.1016/j.envint.2015.11.007
M3 - Journal article
C2 - 26641521
VL - 87
SP - 66
EP - 73
JO - Environment international
JF - Environment international
SN - 0160-4120
ER -
ID: 150781498