Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation
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Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation. / Zeller-Plumhoff, Berit; Akkineni, Ashwini Rahul; Helmholz, Heike; Orlov, Dmytro; Mosshammer, Maria; Kuehl, Michael; Willumeit-Roemer, Regine; Gelinsky, Michael.
In: npj Materials Degradation, Vol. 6, 95, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oxygen-sensitive nanoparticles reveal the spatiotemporal dynamics of oxygen reduction during magnesium implant biodegradation
AU - Zeller-Plumhoff, Berit
AU - Akkineni, Ashwini Rahul
AU - Helmholz, Heike
AU - Orlov, Dmytro
AU - Mosshammer, Maria
AU - Kuehl, Michael
AU - Willumeit-Roemer, Regine
AU - Gelinsky, Michael
PY - 2022
Y1 - 2022
N2 - Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O-2) consumption is non-negligible. In this study, we give experimental proof of O-2 consumption during Mg degradation under physiological conditions. Specifically, we study pure Mg, Mg-6 wt%Ag and Mg-5 wt%Gd in Hanks' balanced salt solution and Dulbecco's modified Eagle's medium. We show that O-2 consumption and hydrogen evolution are inversely correlated and that O-2 concentrations remain below 7.5% in certain cases, which could have significant implications for bone healing.
AB - Magnesium (Mg) alloys are becoming increasingly important in the biomedical field as temporary bone implants. However, the biodegradation process of Mg alloys is highly complex and recent findings suggest that oxygen (O-2) consumption is non-negligible. In this study, we give experimental proof of O-2 consumption during Mg degradation under physiological conditions. Specifically, we study pure Mg, Mg-6 wt%Ag and Mg-5 wt%Gd in Hanks' balanced salt solution and Dulbecco's modified Eagle's medium. We show that O-2 consumption and hydrogen evolution are inversely correlated and that O-2 concentrations remain below 7.5% in certain cases, which could have significant implications for bone healing.
KW - PHYSIOLOGICAL CONDITIONS
KW - PURE MAGNESIUM
KW - DEGRADATION
KW - IMAGE
KW - LAYER
KW - MG
U2 - 10.1038/s41529-022-00302-9
DO - 10.1038/s41529-022-00302-9
M3 - Journal article
VL - 6
JO - npj Materials Degradation
JF - npj Materials Degradation
SN - 2397-2106
M1 - 95
ER -
ID: 329202734