Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin? / Kücükakin, Bülent; Gögenur, Ismail; Reiter, Russel J; Rosenberg, Jacob.

In: Journal of Surgical Research, Vol. 152, No. 2, 2009, p. 338-47.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kücükakin, B, Gögenur, I, Reiter, RJ & Rosenberg, J 2009, 'Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?', Journal of Surgical Research, vol. 152, no. 2, pp. 338-47. https://doi.org/10.1016/j.jss.2007.12.753

APA

Kücükakin, B., Gögenur, I., Reiter, R. J., & Rosenberg, J. (2009). Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin? Journal of Surgical Research, 152(2), 338-47. https://doi.org/10.1016/j.jss.2007.12.753

Vancouver

Kücükakin B, Gögenur I, Reiter RJ, Rosenberg J. Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin? Journal of Surgical Research. 2009;152(2):338-47. https://doi.org/10.1016/j.jss.2007.12.753

Author

Kücükakin, Bülent ; Gögenur, Ismail ; Reiter, Russel J ; Rosenberg, Jacob. / Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?. In: Journal of Surgical Research. 2009 ; Vol. 152, No. 2. pp. 338-47.

Bibtex

@article{ad1ba6a0829611df928f000ea68e967b,
title = "Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?",
abstract = "During and after surgical procedures, there is a well defined physiological stress response that involves activation of inflammatory, endocrine, metabolic, and immunological mediators. Oxidative stress, which is defined to be a situation where the production of reactive oxygen/nitrogen species exceeds the mechanisms required to detoxify them, is believed to be an integrated part of the surgical stress response. Oxidative stress per se may be associated with complications such as myocardial injury, sepsis, pulmonary edema, kidney and liver failure, and increased mortality. Melatonin is a potent antioxidant and in many studies melatonin has been shown to be more effective than some {"}classical{"} antioxidants (e.g., vitamins E and C) in protecting against oxidative/nitrosative stress. There are numerous experimental studies in which the antioxidant properties of melatonin have been proven. In preliminary studies in newborns with asphyxia, sepsis, or respiratory distress syndrome, melatonin has proven to be a highly potent antioxidant. This review summarizes the results of animal and human studies wherein melatonin was shown to modulate oxidative stress; this discussion emphasizes the stress response related to surgery.",
author = "B{\"u}lent K{\"u}c{\"u}kakin and Ismail G{\"o}genur and Reiter, {Russel J} and Jacob Rosenberg",
note = "Keywords: Antioxidants; Circadian Rhythm; Humans; Melatonin; Oxidative Stress; Pulmonary Edema; Surgical Procedures, Operative",
year = "2009",
doi = "10.1016/j.jss.2007.12.753",
language = "English",
volume = "152",
pages = "338--47",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press",
number = "2",

}

RIS

TY - JOUR

T1 - Oxidative stress in relation to surgery: is there a role for the antioxidant melatonin?

AU - Kücükakin, Bülent

AU - Gögenur, Ismail

AU - Reiter, Russel J

AU - Rosenberg, Jacob

N1 - Keywords: Antioxidants; Circadian Rhythm; Humans; Melatonin; Oxidative Stress; Pulmonary Edema; Surgical Procedures, Operative

PY - 2009

Y1 - 2009

N2 - During and after surgical procedures, there is a well defined physiological stress response that involves activation of inflammatory, endocrine, metabolic, and immunological mediators. Oxidative stress, which is defined to be a situation where the production of reactive oxygen/nitrogen species exceeds the mechanisms required to detoxify them, is believed to be an integrated part of the surgical stress response. Oxidative stress per se may be associated with complications such as myocardial injury, sepsis, pulmonary edema, kidney and liver failure, and increased mortality. Melatonin is a potent antioxidant and in many studies melatonin has been shown to be more effective than some "classical" antioxidants (e.g., vitamins E and C) in protecting against oxidative/nitrosative stress. There are numerous experimental studies in which the antioxidant properties of melatonin have been proven. In preliminary studies in newborns with asphyxia, sepsis, or respiratory distress syndrome, melatonin has proven to be a highly potent antioxidant. This review summarizes the results of animal and human studies wherein melatonin was shown to modulate oxidative stress; this discussion emphasizes the stress response related to surgery.

AB - During and after surgical procedures, there is a well defined physiological stress response that involves activation of inflammatory, endocrine, metabolic, and immunological mediators. Oxidative stress, which is defined to be a situation where the production of reactive oxygen/nitrogen species exceeds the mechanisms required to detoxify them, is believed to be an integrated part of the surgical stress response. Oxidative stress per se may be associated with complications such as myocardial injury, sepsis, pulmonary edema, kidney and liver failure, and increased mortality. Melatonin is a potent antioxidant and in many studies melatonin has been shown to be more effective than some "classical" antioxidants (e.g., vitamins E and C) in protecting against oxidative/nitrosative stress. There are numerous experimental studies in which the antioxidant properties of melatonin have been proven. In preliminary studies in newborns with asphyxia, sepsis, or respiratory distress syndrome, melatonin has proven to be a highly potent antioxidant. This review summarizes the results of animal and human studies wherein melatonin was shown to modulate oxidative stress; this discussion emphasizes the stress response related to surgery.

U2 - 10.1016/j.jss.2007.12.753

DO - 10.1016/j.jss.2007.12.753

M3 - Journal article

C2 - 18262562

VL - 152

SP - 338

EP - 347

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 2

ER -

ID: 20544031