Over-estimation of glomerular filtration rate by single injection [51Cr]EDTA plasma clearance determination in patients with ascites
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Over-estimation of glomerular filtration rate by single injection [51Cr]EDTA plasma clearance determination in patients with ascites. / Henriksen, Jens Henrik Sahl; Brøchner-Mortensen, J; Malchow-Møller, A; Schlichting, P.
In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 40, No. 3, 1980, p. 279-84.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Over-estimation of glomerular filtration rate by single injection [51Cr]EDTA plasma clearance determination in patients with ascites
AU - Henriksen, Jens Henrik Sahl
AU - Brøchner-Mortensen, J
AU - Malchow-Møller, A
AU - Schlichting, P
N1 - Keywords: Adult; Age Factors; Ascites; Body Weight; Chromium Radioisotopes; Creatinine; Edetic Acid; Female; Glomerular Filtration Rate; Humans; Kidney; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors
PY - 1980
Y1 - 1980
N2 - The total plasma (Clt) and the renal plasma (Clr) clearances of [51Cr]EDTA were determined simultaneously in nine patients with ascites due to liver cirrhosis. Clt (mean 78 ml/min, range 34-115 ml/min) was significantly higher than Clr (mean 52 ml/min, range 13-96 ml/min, P < 0.005). The ascitic fluid-plasma activity ratio of [51Cr]EDTA increased throughout the investigation period (5h). The results suggest that [51Cr]EDTA equilibrates slowly with the peritoneal space which indicates that Clt will over-estimate the glomerular filtration rate by approximately 20 ml/min in patients with ascites. To assess glomerular filtration rate in presence of ascites, the renal plasma clearance of [51Cr]EDTA should be used instead of the total plasma clearance.
AB - The total plasma (Clt) and the renal plasma (Clr) clearances of [51Cr]EDTA were determined simultaneously in nine patients with ascites due to liver cirrhosis. Clt (mean 78 ml/min, range 34-115 ml/min) was significantly higher than Clr (mean 52 ml/min, range 13-96 ml/min, P < 0.005). The ascitic fluid-plasma activity ratio of [51Cr]EDTA increased throughout the investigation period (5h). The results suggest that [51Cr]EDTA equilibrates slowly with the peritoneal space which indicates that Clt will over-estimate the glomerular filtration rate by approximately 20 ml/min in patients with ascites. To assess glomerular filtration rate in presence of ascites, the renal plasma clearance of [51Cr]EDTA should be used instead of the total plasma clearance.
M3 - Journal article
C2 - 6777855
VL - 40
SP - 279
EP - 284
JO - Scandinavian Journal of Clinical & Laboratory Investigation
JF - Scandinavian Journal of Clinical & Laboratory Investigation
SN - 0036-5513
IS - 3
ER -
ID: 19398521