Out-of-hospital cardiac arrest: 30-day survival and 1-year risk of anoxic brain damage or nursing home admission according to consciousness status at hospital arrival
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Out-of-hospital cardiac arrest : 30-day survival and 1-year risk of anoxic brain damage or nursing home admission according to consciousness status at hospital arrival. / Sondergaard, Kathrine B; Riddersholm, Signe; Wissenberg, Mads; Moller Hansen, Steen; Barcella, Carlo Alberto; Karlsson, Lena; Bundgaard, Kristian; Lippert, Freddy K; Kjaergaard, Jesper; Gislason, Gunnar H; Folke, Fredrik; Torp-Pedersen, Christian; Kragholm, Kristian.
In: Resuscitation, Vol. 148, 2020, p. 251-258.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Out-of-hospital cardiac arrest
T2 - 30-day survival and 1-year risk of anoxic brain damage or nursing home admission according to consciousness status at hospital arrival
AU - Sondergaard, Kathrine B
AU - Riddersholm, Signe
AU - Wissenberg, Mads
AU - Moller Hansen, Steen
AU - Barcella, Carlo Alberto
AU - Karlsson, Lena
AU - Bundgaard, Kristian
AU - Lippert, Freddy K
AU - Kjaergaard, Jesper
AU - Gislason, Gunnar H
AU - Folke, Fredrik
AU - Torp-Pedersen, Christian
AU - Kragholm, Kristian
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2020
Y1 - 2020
N2 - AIM: To investigate the association between consciousness status at hospital arrival and long-term outcomes in out-of-hospital cardiac arrest (OHCA) patients.METHODS: OHCAs between 18-100 years of age were identified from the Danish Cardiac Arrest Registry during 2005-2014. Patients with return of spontaneous circulation (ROSC) or ongoing cardiopulmonary resuscitation (CPR) at hospital arrival were included. Thirty-day survival was evaluated using Kaplan-Meier estimates. Risk of anoxic brain damage or nursing home admission and return to work among 30-day survivors were evaluated using Aalen-Johansen estimates and cause-specific Cox regression.RESULTS: Upon hospital arrival of 13,953 OHCA patients, 776 (5.6%) had ROSC and were conscious (Glasgow Coma Score [GCS]>8), 5205 (37.3%) had ROSC, but were comatose (GCS ≤ 8), and 7972 (57.1%) had ongoing CPR. Thirty-day survival according to status at hospital arrival among patients that were conscious, comatose, or had ongoing CPR was 89.0% (95% confidence interval [CI] 86.8%-91.2%), 39.0% (95% CI 37.6%-40.3%), and 1.2% (95% CI 1.0%-1.4%), respectively. Among 30-day survivors, 1-year risks of new onset anoxic brain damage or nursing home admission according to consciousness status were 2.4% (95% CI 1.2%-3.6%), 12.9% (95% CI 11.4%-14.3%), and 19.4% (95% CI 11.3%-27.4%), respectively. Among 30-day working-age survivors, more than 65% in each group returned to work within 5 years.CONCLUSION: Consciousness status at hospital arrival was strongly associated with 30-day survival in OHCA patients. Among 30-day survivors, a minority was diagnosed with anoxic brain damage or admitted to a nursing home and the majority returned to work independent of consciousness status at hospital arrival.
AB - AIM: To investigate the association between consciousness status at hospital arrival and long-term outcomes in out-of-hospital cardiac arrest (OHCA) patients.METHODS: OHCAs between 18-100 years of age were identified from the Danish Cardiac Arrest Registry during 2005-2014. Patients with return of spontaneous circulation (ROSC) or ongoing cardiopulmonary resuscitation (CPR) at hospital arrival were included. Thirty-day survival was evaluated using Kaplan-Meier estimates. Risk of anoxic brain damage or nursing home admission and return to work among 30-day survivors were evaluated using Aalen-Johansen estimates and cause-specific Cox regression.RESULTS: Upon hospital arrival of 13,953 OHCA patients, 776 (5.6%) had ROSC and were conscious (Glasgow Coma Score [GCS]>8), 5205 (37.3%) had ROSC, but were comatose (GCS ≤ 8), and 7972 (57.1%) had ongoing CPR. Thirty-day survival according to status at hospital arrival among patients that were conscious, comatose, or had ongoing CPR was 89.0% (95% confidence interval [CI] 86.8%-91.2%), 39.0% (95% CI 37.6%-40.3%), and 1.2% (95% CI 1.0%-1.4%), respectively. Among 30-day survivors, 1-year risks of new onset anoxic brain damage or nursing home admission according to consciousness status were 2.4% (95% CI 1.2%-3.6%), 12.9% (95% CI 11.4%-14.3%), and 19.4% (95% CI 11.3%-27.4%), respectively. Among 30-day working-age survivors, more than 65% in each group returned to work within 5 years.CONCLUSION: Consciousness status at hospital arrival was strongly associated with 30-day survival in OHCA patients. Among 30-day survivors, a minority was diagnosed with anoxic brain damage or admitted to a nursing home and the majority returned to work independent of consciousness status at hospital arrival.
U2 - 10.1016/j.resuscitation.2019.12.006
DO - 10.1016/j.resuscitation.2019.12.006
M3 - Journal article
C2 - 31857141
VL - 148
SP - 251
EP - 258
JO - Resuscitation
JF - Resuscitation
SN - 0300-9572
ER -
ID: 257029453