Optical coherence tomography for presurgical delineation of basal cell carcinomas on the face—A comparison with histopathology
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Optical coherence tomography for presurgical delineation of basal cell carcinomas on the face—A comparison with histopathology. / Holm, K. B.E.; Nielsen, L. J.; Lock-Andersen, J.; Behrendt, N.; Svensson, M. S.; Themstrup, L.; Jemec, G. B.E.
In: Journal of Cutaneous Pathology, Vol. 50, No. 5, 2023, p. 441-449.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Optical coherence tomography for presurgical delineation of basal cell carcinomas on the face—A comparison with histopathology
AU - Holm, K. B.E.
AU - Nielsen, L. J.
AU - Lock-Andersen, J.
AU - Behrendt, N.
AU - Svensson, M. S.
AU - Themstrup, L.
AU - Jemec, G. B.E.
N1 - Publisher Copyright: © 2023 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Background: To minimize the risk of incomplete excision of basal cell carcinomas (BCC) the macroscopic tumor margins should be adequately defined. Optical coherence tomography (OCT) is a non-invasive imaging tool that can provide structural and vascular information about skin cancer lesions. The study objective was to compare the presurgical delineation of facial BCC by clinical examination, histopathology, and OCT imaging in tumors undergoing full excision. Methods: Ten patients with BCC lesions on the face were examined clinically, with OCT and histopathology at 3-mm intervals, from the clinical lesion border and beyond the resection line. The OCT scans were evaluated blinded and a delineation estimate of each BCC lesion was made. The results were compared to the clinical and histopathologic results. Results: OCT evaluations and histopathology were in agreement in 86.6% of the collected data points. In three cases the OCT scans estimated a reduction of the tumor size compared to the clinical tumor border set by the surgeon. Conclusion: The results of this study support the notion that OCT can have a role in the clinical daily practice by aiding clinicians in delineating BCC lesions before surgery.
AB - Background: To minimize the risk of incomplete excision of basal cell carcinomas (BCC) the macroscopic tumor margins should be adequately defined. Optical coherence tomography (OCT) is a non-invasive imaging tool that can provide structural and vascular information about skin cancer lesions. The study objective was to compare the presurgical delineation of facial BCC by clinical examination, histopathology, and OCT imaging in tumors undergoing full excision. Methods: Ten patients with BCC lesions on the face were examined clinically, with OCT and histopathology at 3-mm intervals, from the clinical lesion border and beyond the resection line. The OCT scans were evaluated blinded and a delineation estimate of each BCC lesion was made. The results were compared to the clinical and histopathologic results. Results: OCT evaluations and histopathology were in agreement in 86.6% of the collected data points. In three cases the OCT scans estimated a reduction of the tumor size compared to the clinical tumor border set by the surgeon. Conclusion: The results of this study support the notion that OCT can have a role in the clinical daily practice by aiding clinicians in delineating BCC lesions before surgery.
KW - basal cell carcinoma
KW - dermatologic oncology
KW - non-invasive imaging
KW - optical coherence tomography
KW - tumor delineation
U2 - 10.1111/cup.14412
DO - 10.1111/cup.14412
M3 - Journal article
C2 - 36794511
AN - SCOPUS:85150433876
VL - 50
SP - 441
EP - 449
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 5
ER -
ID: 359557343