Optic Nerve Head Anatomy and Vascular Risk Factors in Patients With Optic Disc Drusen Associated Anterior Ischemic Optic Neuropathy
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- Fulltext
Final published version, 0.98 MB, PDF document
Purpose: Optic disc drusen (ODD) is an anatomical risk factor for nonarteritic anterior ischemic optic neuropathy (NA-AION). This study aimed to investigate the anatomical and vascular risk factors of patients with ODD-AION (ODD-associated NA-AION) and compare them with similar data from patients with nODD-AION (NA-AION without ODD). Design:: Case-control study. Methods: Thirty-four ODD-AION and 34 nODD-AION patients who had all been systematically optical coherence tomography scanned using a standardized ODD scanning protocol were retrospectively analyzed and compared regarding demographics, vascular risk factors, clinical characteristics, and specific optic nerve head anatomical characteristics. Results: In patients with ODD-AION, the ODD were predominantly deeply located (82%) but with no significant difference in size (52% large, 48% small). When compared with nODD-AION patients, ODD-AION patients were significantly younger at the time of diagnosis (P = .012) and had fewer vascular risk factors (P = .015). The ODD-AION patients had significantly more peripapillary hyperreflective ovoid mass-like structures (PHOMS) (P < .001) and prelaminar hyperreflective lines (P < .001) as well as smaller Bruch's membrane opening diameters (P = .017) compared with nODD-AION patients. No significant differences were found between ODD-AION and nODD-AION patients regarding visual acuity, refraction, lamina cribrosa position, ganglion cell layer volume, or retinal nerve fiber layer thickness. Conclusion: In ODD-AION, location of the ODD within the optic nerve head is important, while the size of the ODD is not. The ODD-AION and nODD-AION patients presented with distinctly different vascular risk factors and anatomical characteristics, establishing ODD and potentially also PHOMS as independent risk factors for developing NA-AION.
Original language | English |
---|---|
Journal | American Journal of Ophthalmology |
Volume | 242 |
Pages (from-to) | 156-164 |
ISSN | 0002-9394 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Funding Information:
Funding: The VELUX Foundation, Tobaksvejen 10, DK-2860 Søborg, Denmark. Financial Disclosures: No financial disclosures. Conflict of Interests: The authors report no conflict of interest. All authors attest that they meet the current ICMJE criteria for authorship. Author Contributions: R.G.J: Conceptualization, Methodology, Investigation, Data collection, Data analysis, Writing; original draft, Writing; editing. L.L: Conceptualization, Methodology, Investigation, Writing; editing & Data collection. M.J: Investigation & Data analysis. L.M: Investigation & Data curation. S.H: Conceptualization, Methodology, Validation, Investigation, Writing; editing, Supervision & Project administration. All authors approved the final version of the manuscript.
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 325830504