Optic disc drusen: Dystrophic calcification, a potential target for treatment
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Optic disc drusen : Dystrophic calcification, a potential target for treatment. / Bentin, Josephine Mejdahl; Heegaard, Steffen; Jørgensen, Niklas Rye; Grahnemo, Louise; Hamann, Steffen.
In: Eye, Vol. 38, No. 12, 2024, p. 2359-2364.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Optic disc drusen
T2 - Dystrophic calcification, a potential target for treatment
AU - Bentin, Josephine Mejdahl
AU - Heegaard, Steffen
AU - Jørgensen, Niklas Rye
AU - Grahnemo, Louise
AU - Hamann, Steffen
N1 - Publisher Copyright: © The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2024.
PY - 2024
Y1 - 2024
N2 - Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.
AB - Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.
U2 - 10.1038/s41433-024-03138-6
DO - 10.1038/s41433-024-03138-6
M3 - Review
C2 - 38778137
AN - SCOPUS:85193817132
VL - 38
SP - 2359
EP - 2364
JO - Eye
JF - Eye
SN - 0950-222X
IS - 12
ER -
ID: 393464285