Oestrogen-related cancer risk in mothers of testicular-cancer patients
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Oestrogen-related cancer risk in mothers of testicular-cancer patients. / Kroman, Niels; Frisch, Morten; Olsen, Jørgen H.; Westergaard, Tine; Melbye, Mads.
In: International Journal of Cancer, Vol. 66, No. 4, 16.05.1996, p. 438-440.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oestrogen-related cancer risk in mothers of testicular-cancer patients
AU - Kroman, Niels
AU - Frisch, Morten
AU - Olsen, Jørgen H.
AU - Westergaard, Tine
AU - Melbye, Mads
PY - 1996/5/16
Y1 - 1996/5/16
N2 - The belief that oestrogens are involved in the pathogenesis both of testicular cancer in young men and of cancers of the endometrium and female breast has become widespread. In a search for possible hormonal links between these cancers, we investigated the cancer pattern in a cohort of women who had given birth to sons who developed testicular cancer. particular focus was given to oestrogen-related cancers. The present retrospective population-based cohort study is based on data from the Danish Cancer Registry. Mothers of 2,204 testicular-cancer patients were followed for the occurrence of cancer over a total of 70,063 person years. The ratio of observed cancers in the cohort over the expected numbers based on cancer incidence in the underlying female population served as measure of the relative risk (RR). The RR of developing breast cancer among mothers of testicular-cancer patients was 0.8 (95% confidence interval 0.6-1.1), the relative risk of endometrial cancer 0.6 (0.3-1.0) and of ovarian cancer 1.0 (0.6-1.6). Mothers of testicular-cancer patients are not at increased risk of developing oestrogen-related cancers.
AB - The belief that oestrogens are involved in the pathogenesis both of testicular cancer in young men and of cancers of the endometrium and female breast has become widespread. In a search for possible hormonal links between these cancers, we investigated the cancer pattern in a cohort of women who had given birth to sons who developed testicular cancer. particular focus was given to oestrogen-related cancers. The present retrospective population-based cohort study is based on data from the Danish Cancer Registry. Mothers of 2,204 testicular-cancer patients were followed for the occurrence of cancer over a total of 70,063 person years. The ratio of observed cancers in the cohort over the expected numbers based on cancer incidence in the underlying female population served as measure of the relative risk (RR). The RR of developing breast cancer among mothers of testicular-cancer patients was 0.8 (95% confidence interval 0.6-1.1), the relative risk of endometrial cancer 0.6 (0.3-1.0) and of ovarian cancer 1.0 (0.6-1.6). Mothers of testicular-cancer patients are not at increased risk of developing oestrogen-related cancers.
UR - http://www.scopus.com/inward/record.url?scp=0029890270&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0215(19960516)66:4<438::AID-IJC5>3.0.CO;2-X
DO - 10.1002/(SICI)1097-0215(19960516)66:4<438::AID-IJC5>3.0.CO;2-X
M3 - Journal article
C2 - 8635857
AN - SCOPUS:0029890270
VL - 66
SP - 438
EP - 440
JO - Acta - Unio Internationalis Contra Cancrum
JF - Acta - Unio Internationalis Contra Cancrum
SN - 0898-6924
IS - 4
ER -
ID: 259820703