Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis
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Obstetric and neonatal complications in pregnancies conceived after oocyte donation : a systematic review and meta-analysis. / Storgaard, M.; Loft, A.; Bergh, C.; Wennerholm, UB; Söderström-Anttila, V.; Romundstad, LB; Aittomaki, K.; Oldereid, N.; Forman, J.; Pinborg, A.
In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 124, No. 4, 03.2017, p. 561–572.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Obstetric and neonatal complications in pregnancies conceived after oocyte donation
T2 - a systematic review and meta-analysis
AU - Storgaard, M.
AU - Loft, A.
AU - Bergh, C.
AU - Wennerholm, UB
AU - Söderström-Anttila, V.
AU - Romundstad, LB
AU - Aittomaki, K.
AU - Oldereid, N.
AU - Forman, J.
AU - Pinborg, A.
PY - 2017/3
Y1 - 2017/3
N2 - Background: Approximately 50 000 oocyte donation (OD) treatment cycles are now performed annually in Europe and the US.Objectives: To ascertain whether the risk of adverse obstetric and perinatal/neonatal outcomes is higher in pregnancies conceived by OD than in pregnancies conceived by conventional in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or spontaneously.Search Strategy: A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982–2016. Primary outcomes were hypertensive disorders of pregnancy, pre-eclampsia (PE), gestational diabetes mellitus, postpartum haemorrhage, caesarean section, preterm birth, low birthweight and small for gestational age.Selection criteria: Inclusion criteria were original studies including at least five OD pregnancies with a control group of pregnancies conceived by conventional IVF/ICSI or spontaneous conception, and case series with >500 cases reporting one or more of the selected complications. Studies not adjusting for plurality were excluded.Data collection and analysis: Thirty-five studies met the inclusion criteria. A random-effects model was used for the meta-analyses.Main results: For OD pregnancies versus conventional IVF/ICSI pregnancies the risk of PE was adjusted odds ratio (AOR) 2.11 (95% CI, 1.42–3.15) in singleton and AOR 3.31 (95% CI, 1.61–6.80) in multiple pregnancies. The risks of preterm birth and low birthweight in singletons were AOR 1.75 (95% CI, 1.39–2.20) and 1.53 (95% CI, 1.16–2.01), respectively.Conclusions: OD conceptions are associated with adverse obstetric and neonatal outcomes. To avoid the additional increase in risk from multiplicity, single-embryo transfer should be the choice of option in OD cycles.
AB - Background: Approximately 50 000 oocyte donation (OD) treatment cycles are now performed annually in Europe and the US.Objectives: To ascertain whether the risk of adverse obstetric and perinatal/neonatal outcomes is higher in pregnancies conceived by OD than in pregnancies conceived by conventional in-vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) or spontaneously.Search Strategy: A systematic search was performed in the PubMed, Cochrane and Embase databases from 1982–2016. Primary outcomes were hypertensive disorders of pregnancy, pre-eclampsia (PE), gestational diabetes mellitus, postpartum haemorrhage, caesarean section, preterm birth, low birthweight and small for gestational age.Selection criteria: Inclusion criteria were original studies including at least five OD pregnancies with a control group of pregnancies conceived by conventional IVF/ICSI or spontaneous conception, and case series with >500 cases reporting one or more of the selected complications. Studies not adjusting for plurality were excluded.Data collection and analysis: Thirty-five studies met the inclusion criteria. A random-effects model was used for the meta-analyses.Main results: For OD pregnancies versus conventional IVF/ICSI pregnancies the risk of PE was adjusted odds ratio (AOR) 2.11 (95% CI, 1.42–3.15) in singleton and AOR 3.31 (95% CI, 1.61–6.80) in multiple pregnancies. The risks of preterm birth and low birthweight in singletons were AOR 1.75 (95% CI, 1.39–2.20) and 1.53 (95% CI, 1.16–2.01), respectively.Conclusions: OD conceptions are associated with adverse obstetric and neonatal outcomes. To avoid the additional increase in risk from multiplicity, single-embryo transfer should be the choice of option in OD cycles.
KW - Caesarean section
KW - Low birthweight
KW - Oocyte donation
KW - Pre-eclampsia
KW - Preterm birth
U2 - 10.1111/1471-0528.14257
DO - 10.1111/1471-0528.14257
M3 - Review
C2 - 27592694
VL - 124
SP - 561
EP - 572
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
SN - 0140-7686
IS - 4
ER -
ID: 172470938