N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.
Research output: Contribution to journal › Journal article › Research › peer-review
The hippocampal lesion induced by cerebral ischemia has several excitotoxic features. Denervation of the ischemia-vulnerable pyramidal cells has a protective effect. Because most synapses are glutamatergic, administration of glutamate antagonists after ischemia also could be protective. Growing evidence now indicates that non-N-methyl-D-aspartate antagonists are more effective than N-methyl-D-aspartate antagonists in complete global ischemia. One explanation offered is that ischemia may sensitize pyramidal neurons so that "normal" postischemic synaptic activity induces lethal damage.
Original language | English |
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Journal | Stroke |
Volume | 21 |
Issue number | 11 Suppl |
Pages (from-to) | III39-42 |
ISSN | 0039-2499 |
Publication status | Published - 1990 |
Externally published | Yes |
Bibliographical note
Keywords: Animals; Brain Ischemia; Glutamates; Hippocampus; N-Methylaspartate
ID: 5259394