Neurotransmitter transporters: molecular function of important drug targets
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Neurotransmitter transporters : molecular function of important drug targets. / Gether, Ulrik; Andersen, Peter H; Larsson, Orla M; Schousboe, Arne.
In: Trends in Pharmacological Sciences, Vol. 27, No. 7, 07.2006, p. 375-83.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neurotransmitter transporters
T2 - molecular function of important drug targets
AU - Gether, Ulrik
AU - Andersen, Peter H
AU - Larsson, Orla M
AU - Schousboe, Arne
PY - 2006/7
Y1 - 2006/7
N2 - The concentration of neurotransmitters in the extracellular space is tightly controlled by distinct classes of membrane transport proteins. This review focuses on the molecular function of two major classes of neurotransmitter transporter that are present in the cell membrane of neurons and/or glial cells: the solute carrier (SLC)1 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of glutamate, and the SLC6 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of dopamine, 5-HT, norepinephrine, glycine and GABA. Recent research has provided substantial insight into the structure and function of these transporters. In particular, the recent crystallizations of bacterial homologs are of the utmost importance, enabling the first reliable structural models of the mammalian neurotransmitter transporters to be generated. These models should be an important tool for developing specific drugs that, through selective interaction with transporters, could improve the treatment of serious neurological and psychiatric disorders.
AB - The concentration of neurotransmitters in the extracellular space is tightly controlled by distinct classes of membrane transport proteins. This review focuses on the molecular function of two major classes of neurotransmitter transporter that are present in the cell membrane of neurons and/or glial cells: the solute carrier (SLC)1 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of glutamate, and the SLC6 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of dopamine, 5-HT, norepinephrine, glycine and GABA. Recent research has provided substantial insight into the structure and function of these transporters. In particular, the recent crystallizations of bacterial homologs are of the utmost importance, enabling the first reliable structural models of the mammalian neurotransmitter transporters to be generated. These models should be an important tool for developing specific drugs that, through selective interaction with transporters, could improve the treatment of serious neurological and psychiatric disorders.
KW - Animals
KW - Humans
KW - Models, Molecular
KW - Neurotransmitter Transport Proteins
KW - Protein Structure, Quaternary
KW - Protein Structure, Tertiary
KW - Receptors, Drug
U2 - 10.1016/j.tips.2006.05.003
DO - 10.1016/j.tips.2006.05.003
M3 - Journal article
C2 - 16762425
VL - 27
SP - 375
EP - 383
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 7
ER -
ID: 47292780