Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with cerebral palsy: A randomized pilot study
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Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with cerebral palsy : A randomized pilot study. / Bandholm, Thomas Quaade; Jensen, Bente Rona; Nielsen, Lone M; Rasmussen, Helle; Bencke, Jesper; Curtis, Derek; Pedersen, Søren A; Sonne-Holm, Stig.
In: NeuroRehabilitation, Vol. 30, No. 4, 2012, p. 277-286.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neurorehabilitation with versus without resistance training after botulinum toxin treatment in children with cerebral palsy
T2 - A randomized pilot study
AU - Bandholm, Thomas Quaade
AU - Jensen, Bente Rona
AU - Nielsen, Lone M
AU - Rasmussen, Helle
AU - Bencke, Jesper
AU - Curtis, Derek
AU - Pedersen, Søren A
AU - Sonne-Holm, Stig
N1 - CURIS 2012 5200 085
PY - 2012
Y1 - 2012
N2 - Objective: To compare the effects of physical rehabilitation with (PRT) and without (CON) progressive resistance training following treatment of spastic plantarflexors with botulinum toxin type A (BoNT) in children with cerebral palsy (CP). Methods: Fourteen children with CP performed supervised PRT (n=7) or CON (n=7) two times per week for 12 weeks, following the BoNT-treatment. Outcome measurements were performed at baseline (pre BoNT), and 4 and 12 weeks post BoNT. They consisted of: ankle muscle function (maximal torque and submaximal torque steadiness of isometric ankle dorsi- and plantarflexion and associated ankle muscle [EMG] activity), gait function (3-dimensional gait analysis), balance function (sway analysis), gross motor function (GMFM-66), and spasticity (modified Ashworth). Results: Submaximal torque control (torque steadiness) of isometric dorsiflexion improved similarly in the two groups, and the improvement was related to the reduction in antagonist (soleus) co-activity (P<0.05). Maximal plantarflexion torque increased after PRT, whereas a reduction was seen after CON (P<0.05). No changes in function were observed. Conclusions: Both types of physical rehabilitation in combination with BoNT-treatment improved antagonist (ankle dorsiflexion) torque-control to the same extent - which was related to the reduction in antagonist co-activity - but only rehabilitation with PRT increased maximal plantarflexion torque.
AB - Objective: To compare the effects of physical rehabilitation with (PRT) and without (CON) progressive resistance training following treatment of spastic plantarflexors with botulinum toxin type A (BoNT) in children with cerebral palsy (CP). Methods: Fourteen children with CP performed supervised PRT (n=7) or CON (n=7) two times per week for 12 weeks, following the BoNT-treatment. Outcome measurements were performed at baseline (pre BoNT), and 4 and 12 weeks post BoNT. They consisted of: ankle muscle function (maximal torque and submaximal torque steadiness of isometric ankle dorsi- and plantarflexion and associated ankle muscle [EMG] activity), gait function (3-dimensional gait analysis), balance function (sway analysis), gross motor function (GMFM-66), and spasticity (modified Ashworth). Results: Submaximal torque control (torque steadiness) of isometric dorsiflexion improved similarly in the two groups, and the improvement was related to the reduction in antagonist (soleus) co-activity (P<0.05). Maximal plantarflexion torque increased after PRT, whereas a reduction was seen after CON (P<0.05). No changes in function were observed. Conclusions: Both types of physical rehabilitation in combination with BoNT-treatment improved antagonist (ankle dorsiflexion) torque-control to the same extent - which was related to the reduction in antagonist co-activity - but only rehabilitation with PRT increased maximal plantarflexion torque.
U2 - 10.3233/NRE-2012-0756
DO - 10.3233/NRE-2012-0756
M3 - Journal article
C2 - 22672941
VL - 30
SP - 277
EP - 286
JO - NeuroRehabilitation
JF - NeuroRehabilitation
SN - 1053-8135
IS - 4
ER -
ID: 40195797