Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine
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Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine. / Sørensen, Gunnar; Wegener, Gregers; Hasselstrøm, Jørgen; Hansen, Thomas V O; Wörtwein, Gitta; Fink-Jensen, Anders; Woldbye, David P D.
In: NeuroReport, Vol. 20, No. 11, 2009, p. 1023-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine
AU - Sørensen, Gunnar
AU - Wegener, Gregers
AU - Hasselstrøm, Jørgen
AU - Hansen, Thomas V O
AU - Wörtwein, Gitta
AU - Fink-Jensen, Anders
AU - Woldbye, David P D
N1 - Keywords: Analysis of Variance; Animals; Area Under Curve; Catheterization; Chromatography, Liquid; Dopamine; Extracellular Space; Male; Microdialysis; Neuropeptide Y; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry
PY - 2009
Y1 - 2009
N2 - Increases in extracellular dopamine in the shell region of the nucleus accumbens are centrally involved in mediating reinforcement of addictive drugs. Neuropeptide Y (NPY) and its receptors are present in the nucleus accumbens and have been implicated in addiction mechanisms. This study further explored the potential role of NPY in addiction mechanisms using microdialysis to measure extracellular dopamine in vivo after infusion of NPY directly into the accumbal shell region of adult rats. NPY was found to dose-dependently increase extracellular dopamine levels, indicating that NPY could play an important role in drug reinforcement by modulating accumbal dopamine levels
AB - Increases in extracellular dopamine in the shell region of the nucleus accumbens are centrally involved in mediating reinforcement of addictive drugs. Neuropeptide Y (NPY) and its receptors are present in the nucleus accumbens and have been implicated in addiction mechanisms. This study further explored the potential role of NPY in addiction mechanisms using microdialysis to measure extracellular dopamine in vivo after infusion of NPY directly into the accumbal shell region of adult rats. NPY was found to dose-dependently increase extracellular dopamine levels, indicating that NPY could play an important role in drug reinforcement by modulating accumbal dopamine levels
M3 - Journal article
C2 - 19579268
VL - 20
SP - 1023
EP - 1026
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 11
ER -
ID: 16945868