Neurofilament light chain levels in serum among a large mixed memory clinic cohort: Confounders and diagnostic usefulness
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Neurofilament light chain levels in serum among a large mixed memory clinic cohort : Confounders and diagnostic usefulness. / Simonsen, Anja Hviid; Gleerup, Helena Sophia; Musaeus, Christian Sandøe; Sellebjerg, Finn; Hansen, Malene Bredahl; Søndergaard, Helle Bach; Waldemar, Gunhild; Hasselbalch, Steen Gregers.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 15, No. 4, e12512, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Neurofilament light chain levels in serum among a large mixed memory clinic cohort
T2 - Confounders and diagnostic usefulness
AU - Simonsen, Anja Hviid
AU - Gleerup, Helena Sophia
AU - Musaeus, Christian Sandøe
AU - Sellebjerg, Finn
AU - Hansen, Malene Bredahl
AU - Søndergaard, Helle Bach
AU - Waldemar, Gunhild
AU - Hasselbalch, Steen Gregers
N1 - Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023
Y1 - 2023
N2 - INTRODUCTION: Early and accurate diagnosis of neurocognitive disorders including neurodegenerative dementia remains challenging. This study explores the impact of biological factors on serum neurofilament light chain (NfL) levels and clinical usefulness for the detection of neurocognitive disorders in a mixed memory clinic. METHODS: Serum samples and clinical data were obtained from 1188 patients who underwent diagnostic investigations for memory complaints between January 2018 and September 2019. Serum NfL was measured using single molecule array technology. RESULTS: NfL exhibited a moderate association with age, estimated glomerular filtration rate (eGFR), and Fazekas score. NfL was able to differentiate between patients with neurocognitive disorders and those without with a sensitivity and specificity of 80%. NfL could, however, not distinguish between different dementia etiologies. DISCUSSION: Serum NfL could aid early diagnostic triage by identifying patients requiring further diagnostic procedures and therefore aid in a more focused use of health-care resources.
AB - INTRODUCTION: Early and accurate diagnosis of neurocognitive disorders including neurodegenerative dementia remains challenging. This study explores the impact of biological factors on serum neurofilament light chain (NfL) levels and clinical usefulness for the detection of neurocognitive disorders in a mixed memory clinic. METHODS: Serum samples and clinical data were obtained from 1188 patients who underwent diagnostic investigations for memory complaints between January 2018 and September 2019. Serum NfL was measured using single molecule array technology. RESULTS: NfL exhibited a moderate association with age, estimated glomerular filtration rate (eGFR), and Fazekas score. NfL was able to differentiate between patients with neurocognitive disorders and those without with a sensitivity and specificity of 80%. NfL could, however, not distinguish between different dementia etiologies. DISCUSSION: Serum NfL could aid early diagnostic triage by identifying patients requiring further diagnostic procedures and therefore aid in a more focused use of health-care resources.
KW - blood biomarker
KW - dementia
KW - diagnosis
KW - neurodegeneration
KW - neurofilament light chain
U2 - 10.1002/dad2.12512
DO - 10.1002/dad2.12512
M3 - Journal article
C2 - 38094990
AN - SCOPUS:85179359514
VL - 15
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
SN - 2352-8729
IS - 4
M1 - e12512
ER -
ID: 396105224