TY - JOUR

T1 - Neurocognitive Subgroups in Children at Familial High-risk of Schizophrenia or Bipolar disorder

T2 - Subgroup Membership Stability or Change From Age 7 to 11-The Danish High Risk and Resilience Study

AU - Knudsen, Christina Bruun

AU - Greve, Aja Neergaard

AU - Jepsen, Jens Richardt Mollegaard

AU - Lambek, Rikke

AU - Andreassen, Anna Krogh

AU - Veddum, Lotte

AU - Brandt, Julie Marie

AU - Gregersen, Maja

AU - Krantz, Mette Falkenberg

AU - Sondergaard, Anne

AU - Carlsen, Anders Helles

AU - Steffensen, Nanna Lawaetz

AU - Bundgaard, Anette Faurskov

AU - Burton, Birgitte Klee

AU - Thorup, Anne Amalie Elgaard

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Bliksted, Vibeke Fuglsang

AU - Hemager, Nicoline

PY - 2023

Y1 - 2023

N2 - Background and Hypothesis Subgroups with distinct levels of neurocognitive functioning exist in children of parents with schizophrenia or bipolar disorder. However, studies investigating the temporal stability of subgroup membership are currently lacking. We hypothesized that a minority of children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) would transition to a different neurocognitive subgroup from age 7 to 11 and that most transitions would be to a more impaired subgroup. Study Design Latent profile analysis was used to identify subgroups at two assessments (age 7 and 11) based on the performance of 320 children at FHR-SZ or FHR-BP across eight neurocognitive functions. Temporal stability in subgroup membership was evaluated with latent profile transition analysis. Population-based controls (age 7, n = 199; age 11, n = 178) were included as a reference group. Children transitioning to a more impaired subgroup were compared with nontransitioning children on sex, FHR-status, global functioning, and psychopathology. Study Results At both assessment points, we identified three subgroups based on neurocognitive performance: a moderately-severely impaired, a mildly impaired, and an above-average subgroup. A total of 12.8% of children transitioned to a different subgroup, of which the majority (85.2%) moved to a more impaired subgroup. Parental diagnosis of schizophrenia, but neither parental diagnosis of bipolar disorder, global functioning at age 7, psychopathology, nor sex significantly differentiated children transitioning to a more impaired subgroup from nontransitioning children. Conclusions During pre-adolescence, neurocognitive developmental lag is associated with being at FHR-SZ. Close attention to these children's neurocognitive development is indicated.

AB - Background and Hypothesis Subgroups with distinct levels of neurocognitive functioning exist in children of parents with schizophrenia or bipolar disorder. However, studies investigating the temporal stability of subgroup membership are currently lacking. We hypothesized that a minority of children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) would transition to a different neurocognitive subgroup from age 7 to 11 and that most transitions would be to a more impaired subgroup. Study Design Latent profile analysis was used to identify subgroups at two assessments (age 7 and 11) based on the performance of 320 children at FHR-SZ or FHR-BP across eight neurocognitive functions. Temporal stability in subgroup membership was evaluated with latent profile transition analysis. Population-based controls (age 7, n = 199; age 11, n = 178) were included as a reference group. Children transitioning to a more impaired subgroup were compared with nontransitioning children on sex, FHR-status, global functioning, and psychopathology. Study Results At both assessment points, we identified three subgroups based on neurocognitive performance: a moderately-severely impaired, a mildly impaired, and an above-average subgroup. A total of 12.8% of children transitioned to a different subgroup, of which the majority (85.2%) moved to a more impaired subgroup. Parental diagnosis of schizophrenia, but neither parental diagnosis of bipolar disorder, global functioning at age 7, psychopathology, nor sex significantly differentiated children transitioning to a more impaired subgroup from nontransitioning children. Conclusions During pre-adolescence, neurocognitive developmental lag is associated with being at FHR-SZ. Close attention to these children's neurocognitive development is indicated.

KW - severe mental disorders

KW - pre-adolescence

KW - cognitive development

KW - latent profile transition analysis

KW - COGNITIVE HETEROGENEITY

KW - 7-YEAR-OLD CHILDREN

KW - ADULT SCHIZOPHRENIA

KW - PSYCHOSIS

KW - COHORT

KW - ATTENTION

KW - METAANALYSIS

KW - METHODOLOGY

KW - REMEDIATION

KW - PERFORMANCE

U2 - 10.1093/schbul/sbac134

DO - 10.1093/schbul/sbac134

M3 - Journal article

C2 - 36200864

VL - 49

SP - 185

EP - 195

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 1

ER -