Neurobioloy of sleep and circadian disorders
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Neurobioloy of sleep and circadian disorders. / Kornum, Birgitte Rahbek; Mignot, Emmanuel.
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. ed. / Michael J. Zigmond; Clayton A. Wiley; Marie-Francoise Chesselet. 2. ed. Elsevier, 2022. p. 635-658.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Neurobioloy of sleep and circadian disorders
AU - Kornum, Birgitte Rahbek
AU - Mignot, Emmanuel
N1 - Publisher Copyright: © 2023 Elsevier Inc. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Mammalian sleep has evolved under the influence of the day–night cycle and in response to reproductive needs, food seeking, and predator escape, resulting in circadian (predictive) and homeostatic (reactive) regulation. A molecular clock characterized by transcription/translation feedback loops mediates circadian regulation of sleep. Misalignment with the rhythm of the sun results in circadian rhythm disorders and jet lag. The molecular basis of homeostatic sleep regulation is mostly unknown. A network of mutually inhibitory brain nuclei regulates sleep states and sleep–wake transitions. Abnormalities in these networks create sleep disorders, for example, rapid eye movement sleep behavior disorder, sleep walking, or narcolepsy. Physiological changes associated with sleep can also be imbalanced, resulting in excess movements such as periodic leg movements during sleep or abnormal breathing in obstructive sleep apneas. As every organ in the body is affected by sleep directly or indirectly, sleep and sleep-associated disorders are frequent and only now starting to be understood.
AB - Mammalian sleep has evolved under the influence of the day–night cycle and in response to reproductive needs, food seeking, and predator escape, resulting in circadian (predictive) and homeostatic (reactive) regulation. A molecular clock characterized by transcription/translation feedback loops mediates circadian regulation of sleep. Misalignment with the rhythm of the sun results in circadian rhythm disorders and jet lag. The molecular basis of homeostatic sleep regulation is mostly unknown. A network of mutually inhibitory brain nuclei regulates sleep states and sleep–wake transitions. Abnormalities in these networks create sleep disorders, for example, rapid eye movement sleep behavior disorder, sleep walking, or narcolepsy. Physiological changes associated with sleep can also be imbalanced, resulting in excess movements such as periodic leg movements during sleep or abnormal breathing in obstructive sleep apneas. As every organ in the body is affected by sleep directly or indirectly, sleep and sleep-associated disorders are frequent and only now starting to be understood.
KW - Circadian rhythm
KW - Dopamine
KW - Dreaming
KW - GABA
KW - Kleine–Levin syndrome
KW - Narcolepsy
KW - Rapid eye movement behavior disorder
KW - Restless legs syndrome
KW - Serotonin
KW - Sleep
KW - Sleep homeostasis
U2 - 10.1016/B978-0-323-85654-6.00020-4
DO - 10.1016/B978-0-323-85654-6.00020-4
M3 - Book chapter
AN - SCOPUS:85141317943
SN - 9780323898256
SP - 635
EP - 658
BT - Neurobiology of Brain Disorders
A2 - null, Michael J. Zigmond
A2 - null, Clayton A. Wiley
A2 - null, Marie-Francoise Chesselet
PB - Elsevier
ER -
ID: 326842036