Neural responses during down-regulation of negative emotion in patients with recently diagnosed bipolar disorder and their unaffected relatives
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Neural responses during down-regulation of negative emotion in patients with recently diagnosed bipolar disorder and their unaffected relatives. / Kjærstad, Hanne Lie; Macoveanu, Julian; Knudsen, Gitte Moos; Frangou, Sophia; Phan, K. Luan; Vinberg, Maj; Kessing, Lars Vedel; Miskowiak, Kamilla Woznica.
In: Psychological Medicine, Vol. 53, No. 4, 2023, p. 1254-1265.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neural responses during down-regulation of negative emotion in patients with recently diagnosed bipolar disorder and their unaffected relatives
AU - Kjærstad, Hanne Lie
AU - Macoveanu, Julian
AU - Knudsen, Gitte Moos
AU - Frangou, Sophia
AU - Phan, K. Luan
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
AU - Miskowiak, Kamilla Woznica
N1 - Publisher Copyright: © The Author(s), 2021. Published by Cambridge University Press.
PY - 2023
Y1 - 2023
N2 - Background Aberrant emotion regulation has been posited as a putative endophenotype of bipolar disorder (BD). We therefore aimed to compare the neural responses during voluntary down-regulation of negative emotions in a large functional magnetic resonance imaging study of BD, patients' unaffected first-degree relatives (URs), and healthy controls (HCs). Methods We compared neural activity and fronto-limbic functional connectivity during emotion regulation in response to aversive v. neutral pictures in patients recently diagnosed with BD (n = 78) in full/partial remission, their URs (n = 35), and HCs (n = 56). Results Patients showed hypo-activity in the left dorsomedial, dorsolateral, and ventrolateral prefrontal cortex (DMPFC and DLPFC) during emotion regulation while viewing aversive pictures compared to HCs, with URs displaying intermediate neural activity in these regions. There were no significant differences between patients with BD and HCs in functional connectivity from the amygdala during emotion regulation. However, exploratory analysis indicated that URs displayed more negative amygdala-DMPFC coupling compared with HCs and more negative amygdala-cingulate DLPFC coupling compared to patients with BD. At a behavioral level, patients and their URs were less able to dampen negative emotions in response aversive pictures. Conclusions The findings point to deficient recruitment of prefrontal resources and more negative fronto-amygdala coupling as neural markers of impaired emotion regulation in recently diagnosed remitted patients with BD and their URs, respectively.
AB - Background Aberrant emotion regulation has been posited as a putative endophenotype of bipolar disorder (BD). We therefore aimed to compare the neural responses during voluntary down-regulation of negative emotions in a large functional magnetic resonance imaging study of BD, patients' unaffected first-degree relatives (URs), and healthy controls (HCs). Methods We compared neural activity and fronto-limbic functional connectivity during emotion regulation in response to aversive v. neutral pictures in patients recently diagnosed with BD (n = 78) in full/partial remission, their URs (n = 35), and HCs (n = 56). Results Patients showed hypo-activity in the left dorsomedial, dorsolateral, and ventrolateral prefrontal cortex (DMPFC and DLPFC) during emotion regulation while viewing aversive pictures compared to HCs, with URs displaying intermediate neural activity in these regions. There were no significant differences between patients with BD and HCs in functional connectivity from the amygdala during emotion regulation. However, exploratory analysis indicated that URs displayed more negative amygdala-DMPFC coupling compared with HCs and more negative amygdala-cingulate DLPFC coupling compared to patients with BD. At a behavioral level, patients and their URs were less able to dampen negative emotions in response aversive pictures. Conclusions The findings point to deficient recruitment of prefrontal resources and more negative fronto-amygdala coupling as neural markers of impaired emotion regulation in recently diagnosed remitted patients with BD and their URs, respectively.
KW - bipolar disorder
KW - childhood trauma
KW - Emotion regulation
KW - fMRI
KW - functional connectivity
KW - high-risk
KW - relatives
U2 - 10.1017/S0033291721002737
DO - 10.1017/S0033291721002737
M3 - Journal article
C2 - 37010225
AN - SCOPUS:85114088104
VL - 53
SP - 1254
EP - 1265
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 4
ER -
ID: 363360811