Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat.
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Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat. / Tønder, N; Sørensen, T; Johansen, Flemming Fryd; Zimmer, J.
In: Acta Neurobiologiae Experimentalis, Vol. 50, No. 4-5, 1990, p. 367-80.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neural grafting to ischemic and excitotoxic, hippocampal lesions in the adult rat.
AU - Tønder, N
AU - Sørensen, T
AU - Johansen, Flemming Fryd
AU - Zimmer, J
N1 - Keywords: Animals; Animals, Newborn; Axons; Brain Tissue Transplantation; Fetal Tissue Transplantation; Graft Survival; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Pyramidal Tracts; Rats
PY - 1990
Y1 - 1990
N2 - Results of neural grafting to excitotoxic and ischemic lesions of the adult rat hippocampus is reviewed with particular emphasis on the exchange of host-transplant nerve connections. Based on observations obtained by a variety of tracing techniques about 6 weeks after--(i) grafting of pieces of neonatal fascia dentata to one week old ibotenic acid lesions of the adult rat fascia dentata, (ii) grafting of suspensions of late fetal CA3 cells to one week old ibotenic acid lesions of the adult rat CA3--and (iii) grafting of suspensions of late fetal CA1 cells to one week old ischemic lesions of the adult rat CA1, we conclude that axon-sparing lesions of the mentioned types enhance the growth of adult host brain axons of the so called point-to-point type into neural grafts. We interpret these findings as the result of an improved capability of adult host brain axons to participate in the graft host interaxonal competition for synaptic sites in the developing neural grafts. At the same time an extensive growth of graft CA3 and CA1 axons into the host brain was demonstrated.
AB - Results of neural grafting to excitotoxic and ischemic lesions of the adult rat hippocampus is reviewed with particular emphasis on the exchange of host-transplant nerve connections. Based on observations obtained by a variety of tracing techniques about 6 weeks after--(i) grafting of pieces of neonatal fascia dentata to one week old ibotenic acid lesions of the adult rat fascia dentata, (ii) grafting of suspensions of late fetal CA3 cells to one week old ibotenic acid lesions of the adult rat CA3--and (iii) grafting of suspensions of late fetal CA1 cells to one week old ischemic lesions of the adult rat CA1, we conclude that axon-sparing lesions of the mentioned types enhance the growth of adult host brain axons of the so called point-to-point type into neural grafts. We interpret these findings as the result of an improved capability of adult host brain axons to participate in the graft host interaxonal competition for synaptic sites in the developing neural grafts. At the same time an extensive growth of graft CA3 and CA1 axons into the host brain was demonstrated.
M3 - Journal article
C2 - 2130655
VL - 50
SP - 367
EP - 380
JO - Acta Neurobiologiae Experimentalis
JF - Acta Neurobiologiae Experimentalis
SN - 0065-1400
IS - 4-5
ER -
ID: 5259416