Neural cell adhesion molecule (NCAM) and prealbumin in cerebrospinal fluid from depressed patients.
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Neural cell adhesion molecule (NCAM) and prealbumin in cerebrospinal fluid from depressed patients. / Jørgensen, Ole Steen.
In: Acta Psychiatrica Scandinavica. Supplementum, Vol. 345, 1988, p. 29-37.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Neural cell adhesion molecule (NCAM) and prealbumin in cerebrospinal fluid from depressed patients.
AU - Jørgensen, Ole Steen
N1 - Keywords: Antigens, Surface; Cell Adhesion Molecules; Choroid Plexus; Depressive Disorder; Follow-Up Studies; Humans; Prealbumin
PY - 1988
Y1 - 1988
N2 - The size of the soluble form of the human cerebrospinal fluid (CSF) neural cell adhesion molecule, NCAM-sol, was by gel permeation chromatography estimated to 160-250 kDa. Within the CSF the concentration of NCAM-sol was found about 15-25% increased in lumbar fluid and 25% increased in ventricular fluid, both compared to cisternal fluid. Whereas prealbumin was found evenly distributed in CSF, albumin was relatively enriched in lumbar fluid. The concentrations of NCAM-sol and prealbumin were measured in lumbar CSF from psychiatric patients. Prealbumin was increased 7.2% and NCAM-sol was decreased 15.1% in depressed patients. The changes were partially normalized during recovery from the depression. The findings can be explained by hypothesizing that endogenous depression is associated with an increased choroid plexus activity and CSF production.
AB - The size of the soluble form of the human cerebrospinal fluid (CSF) neural cell adhesion molecule, NCAM-sol, was by gel permeation chromatography estimated to 160-250 kDa. Within the CSF the concentration of NCAM-sol was found about 15-25% increased in lumbar fluid and 25% increased in ventricular fluid, both compared to cisternal fluid. Whereas prealbumin was found evenly distributed in CSF, albumin was relatively enriched in lumbar fluid. The concentrations of NCAM-sol and prealbumin were measured in lumbar CSF from psychiatric patients. Prealbumin was increased 7.2% and NCAM-sol was decreased 15.1% in depressed patients. The changes were partially normalized during recovery from the depression. The findings can be explained by hypothesizing that endogenous depression is associated with an increased choroid plexus activity and CSF production.
M3 - Journal article
C2 - 3067538
VL - 345
SP - 29
EP - 37
JO - Acta Psychiatrica Scandinavica. Supplementum
JF - Acta Psychiatrica Scandinavica. Supplementum
SN - 0065-1591
ER -
ID: 5941409