Natural selection and the distribution of identity-by-descent in the human genome
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Natural selection and the distribution of identity-by-descent in the human genome. / Albrechtsen, Anders; Moltke, Ida; Nielsen, Rasmus.
In: Genetics, Vol. 186, No. 1, 2010, p. 295-308.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Natural selection and the distribution of identity-by-descent in the human genome
AU - Albrechtsen, Anders
AU - Moltke, Ida
AU - Nielsen, Rasmus
PY - 2010
Y1 - 2010
N2 - There has recently been considerable interest in detecting natural selection in the human genome. Selection will usually tend to increase identity-by-descent (IBD) among individuals in a population, and many methods for detecting recent and ongoing positive selection indirectly take advantage of this. In this article we show that excess IBD sharing is a general property of natural selection and we show that this fact makes it possible to detect several types of selection including a type that is otherwise difficult to detect: selection acting on standing genetic variation. Motivated by this, we use a recently developed method for identifying IBD sharing among individuals from genome-wide data to scan populations from the new HapMap phase 3 project for regions with excess IBD sharing in order to identify regions in the human genome that have been under strong, very recent selection. The HLA region is by far the region showing the most extreme signal, suggesting that much of the strong recent selection acting on the human genome has been immune related and acting on HLA loci. As equilibrium overdominance does not tend to increase IBD, we argue that this type of selection cannot explain our observations.
AB - There has recently been considerable interest in detecting natural selection in the human genome. Selection will usually tend to increase identity-by-descent (IBD) among individuals in a population, and many methods for detecting recent and ongoing positive selection indirectly take advantage of this. In this article we show that excess IBD sharing is a general property of natural selection and we show that this fact makes it possible to detect several types of selection including a type that is otherwise difficult to detect: selection acting on standing genetic variation. Motivated by this, we use a recently developed method for identifying IBD sharing among individuals from genome-wide data to scan populations from the new HapMap phase 3 project for regions with excess IBD sharing in order to identify regions in the human genome that have been under strong, very recent selection. The HLA region is by far the region showing the most extreme signal, suggesting that much of the strong recent selection acting on the human genome has been immune related and acting on HLA loci. As equilibrium overdominance does not tend to increase IBD, we argue that this type of selection cannot explain our observations.
KW - Alleles
KW - Chromosomes, Human, Pair 8
KW - Evolution, Molecular
KW - Genome, Human
KW - HLA Antigens
KW - Haplotypes
KW - Humans
KW - Models, Genetic
KW - Phylogeny
KW - Probability
KW - Selection, Genetic
U2 - 10.1534/genetics.110.113977
DO - 10.1534/genetics.110.113977
M3 - Journal article
C2 - 20592267
VL - 186
SP - 295
EP - 308
JO - Genetics
JF - Genetics
SN - 1943-2631
IS - 1
ER -
ID: 32959962