Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

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T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.
Original languageEnglish
JournalJournal of Neuroimmunology
Volume127
Issue number1-2
Pages (from-to)59-68
Number of pages10
ISSN0165-5728
Publication statusPublished - Jun 2002

    Research areas

  • Adult, Aged, Astrocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Central Nervous System, Cerebrospinal Fluid, Chemokine CXCL10, Chemokines, CXC, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis, Myelitis, Transverse, Optic Neuritis, Receptors, CXCR3, Receptors, Chemokine

ID: 111410582