Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system
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Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. / Sørensen, Torben Lykke; Trebst, Corinna; Kivisäkk, Pia; Klaege, Karen L; Majmudar, Amit; Ravid, Rivka; Lassmann, Hans; Olsen, David B; Strieter, Robert M; Ransohoff, Richard M; Sellebjerg, Finn.
In: Journal of Neuroimmunology, Vol. 127, No. 1-2, 06.2002, p. 59-68.Research output: Contribution to journal › Journal article › Research
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T1 - Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system
AU - Sørensen, Torben Lykke
AU - Trebst, Corinna
AU - Kivisäkk, Pia
AU - Klaege, Karen L
AU - Majmudar, Amit
AU - Ravid, Rivka
AU - Lassmann, Hans
AU - Olsen, David B
AU - Strieter, Robert M
AU - Ransohoff, Richard M
AU - Sellebjerg, Finn
PY - 2002/6
Y1 - 2002/6
N2 - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.
AB - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.
KW - Adult
KW - Aged
KW - Astrocytes
KW - CD4-Positive T-Lymphocytes
KW - CD8-Positive T-Lymphocytes
KW - Central Nervous System
KW - Cerebrospinal Fluid
KW - Chemokine CXCL10
KW - Chemokines, CXC
KW - Female
KW - Flow Cytometry
KW - Humans
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Myelitis, Transverse
KW - Optic Neuritis
KW - Receptors, CXCR3
KW - Receptors, Chemokine
M3 - Journal article
C2 - 12044976
VL - 127
SP - 59
EP - 68
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -
ID: 111410582