Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients. / Haddow, Lewis J; Laverick, Rosanna; Daskalopoulou, Marina; McDonnell, Jeffrey; Lampe, Fiona C; Gilson, Richard; Speakman, Andrew; Antinori, Andrea; Balestra, Pietro; Bruun, Tina; Gerstoft, Jan; Nielsen, Lars; Vassilenko, Anna; Collins, Simon; Rodger, Alison J; Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group.
In: AIDS & Behavior, Vol. 22, No. 5, 05.2018, p. 1573–1583.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients
AU - Haddow, Lewis J
AU - Laverick, Rosanna
AU - Daskalopoulou, Marina
AU - McDonnell, Jeffrey
AU - Lampe, Fiona C
AU - Gilson, Richard
AU - Speakman, Andrew
AU - Antinori, Andrea
AU - Balestra, Pietro
AU - Bruun, Tina
AU - Gerstoft, Jan
AU - Nielsen, Lars
AU - Vassilenko, Anna
AU - Collins, Simon
AU - Rodger, Alison J
AU - Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
PY - 2018/5
Y1 - 2018/5
N2 - We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤-1 in at least 2 out of 5 cognitive domains. Participants' mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54-0.94) or with a university education (aPR 0.72, 95% CI 0.54-0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09-2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03-1.90).
AB - We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤-1 in at least 2 out of 5 cognitive domains. Participants' mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54-0.94) or with a university education (aPR 0.72, 95% CI 0.54-0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09-2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03-1.90).
U2 - 10.1007/s10461-017-1683-z
DO - 10.1007/s10461-017-1683-z
M3 - Journal article
C2 - 28144792
VL - 22
SP - 1573
EP - 1583
JO - AIDS & Behavior
JF - AIDS & Behavior
SN - 1090-7165
IS - 5
ER -
ID: 195045466