TY - JOUR

T1 - Mucorales-disseminated infection in burn wound

AU - Herbst, Isabella

AU - Helleberg, Marie

AU - Overgaard-Steensen, Christian

AU - Holmgaard, Rikke

N1 - Funding Information: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. Publisher Copyright: © BMJ Publishing Group Limited 2023.

PY - 2023

Y1 - 2023

N2 - A previously fit and well man in his 50s was rescued from a burning apartment with Glasgow Coma Scale 3 and admitted to the burn intensive care unit with 18% mixed dermal and full thickness burns and inhalation injury. He received standardised acute burn treatment according to the Emergency Management of Severe Burn guidelines and was found to have acute kidney injury requiring dialysis and cerebral watershed infarcts. The burns were deep especially on the left leg that was deemed unsalvageable and on day 8, he underwent a mid-femoral amputation. A wound swab on day 8 grew mould and with progression of skin necrosis, Mucorales infection was clinically suspected. Microbiological assessment of the swab confirmed Mucorales infection—an invasive fungus with the ability to invade blood vessels leading to vessel thrombosis and tissue necrosis and associated with high mortality. Recommended radical debridement with free cutaneous margins was not possible due to the widespread disease, and the patient was treated conservatively with antifungal therapy and survived.

AB - A previously fit and well man in his 50s was rescued from a burning apartment with Glasgow Coma Scale 3 and admitted to the burn intensive care unit with 18% mixed dermal and full thickness burns and inhalation injury. He received standardised acute burn treatment according to the Emergency Management of Severe Burn guidelines and was found to have acute kidney injury requiring dialysis and cerebral watershed infarcts. The burns were deep especially on the left leg that was deemed unsalvageable and on day 8, he underwent a mid-femoral amputation. A wound swab on day 8 grew mould and with progression of skin necrosis, Mucorales infection was clinically suspected. Microbiological assessment of the swab confirmed Mucorales infection—an invasive fungus with the ability to invade blood vessels leading to vessel thrombosis and tissue necrosis and associated with high mortality. Recommended radical debridement with free cutaneous margins was not possible due to the widespread disease, and the patient was treated conservatively with antifungal therapy and survived.

U2 - 10.1136/bcr-2022-253879

DO - 10.1136/bcr-2022-253879

M3 - Journal article

C2 - 37914163

AN - SCOPUS:85175769832

VL - 16

JO - BMJ Case Reports

JF - BMJ Case Reports

SN - 1757-790X

IS - 11

M1 - e253879

ER -