MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer - A multicenter prospective comparative study
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MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer - A multicenter prospective comparative study. / Antonsen, Sofie Leisby; Jensen, Lisa Neerup; Loft, Annika; Berthelsen, Anne Kiil; Costa, Junia; Tabor, Ann; Qvist, Ingelise; Hansen, Mette Rodi; Fisker, Rune Vincents; Andersen, Erik Søgaard; Sperling, Lene; Nielsen, Anne Lerberg; Asmussen, Jon; Høgdall, Estrid; Fagö-Olsen, Carsten L; Christensen, Ib Jarle; Nedergaard, Lotte; Jochumsen, Kirsten Væver; Høgdall, Claus.
In: Journal of Gynecologic Oncology Nursing, Vol. 128, No. 2, 2013, p. 300- 8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer - A multicenter prospective comparative study
AU - Antonsen, Sofie Leisby
AU - Jensen, Lisa Neerup
AU - Loft, Annika
AU - Berthelsen, Anne Kiil
AU - Costa, Junia
AU - Tabor, Ann
AU - Qvist, Ingelise
AU - Hansen, Mette Rodi
AU - Fisker, Rune Vincents
AU - Andersen, Erik Søgaard
AU - Sperling, Lene
AU - Nielsen, Anne Lerberg
AU - Asmussen, Jon
AU - Høgdall, Estrid
AU - Fagö-Olsen, Carsten L
AU - Christensen, Ib Jarle
AU - Nedergaard, Lotte
AU - Jochumsen, Kirsten Væver
AU - Høgdall, Claus
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2013
Y1 - 2013
N2 - OBJECTIVES: The aim of this prospective multicenter study was to evaluate and compare the diagnostic performance of PET/CT, MRI and transvaginal two-dimensional ultrasound (2DUS) in the preoperative assessment of endometrial cancer (EC). METHODS: 318 consecutive women with EC were included when referred to three Danish tertiary gynecological centers for surgical treatment. Preoperatively they were PET/CT-, MRI-, and 2DUS scanned. The imaging results were compared to the final pathological findings. This study was approved by the National Committee on Health Research Ethics. RESULTS: For predicting myometrial invasion, we found sensitivity, specificity, PPV, NPV, and accuracy for PET/CT to be 93%, 49%, 41%, 95% and 61%, for MRI to be 87%, 57%, 44%, 92%, and 66% and for 2DUS to be 71%, 72%, 51%, 86% and 72%. For predicting cervical invasion, the values were 43%, 94%, 69%, 85% and 83%, respectively, for PET/CT, 33%, 95%, 60%, 85%, and 82%, respectively, for MRI, and 29%, 92%, 48%, 82% and 78% for 2DUS. Finally, for lymph node metastases, the values were 74%, 93%, 59%, 96%, and 91% for PET/CT and 59%, 93%, 40%, 97% and 90% for MRI. When comparing the diagnostic performance we found PET/CT, MRI and 2DUS to be comparable in predicting myometrial invasion. For cervical invasion and lymph node metastases, however, PET/CT was the best. CONCLUSIONS: None of the modalities can yet replace surgical staging. However, they all contributed to important knowledge and were, furthermore, able to upstage low-risk patients who would not have been recommended lymph node resection based on histology and grade alone.
AB - OBJECTIVES: The aim of this prospective multicenter study was to evaluate and compare the diagnostic performance of PET/CT, MRI and transvaginal two-dimensional ultrasound (2DUS) in the preoperative assessment of endometrial cancer (EC). METHODS: 318 consecutive women with EC were included when referred to three Danish tertiary gynecological centers for surgical treatment. Preoperatively they were PET/CT-, MRI-, and 2DUS scanned. The imaging results were compared to the final pathological findings. This study was approved by the National Committee on Health Research Ethics. RESULTS: For predicting myometrial invasion, we found sensitivity, specificity, PPV, NPV, and accuracy for PET/CT to be 93%, 49%, 41%, 95% and 61%, for MRI to be 87%, 57%, 44%, 92%, and 66% and for 2DUS to be 71%, 72%, 51%, 86% and 72%. For predicting cervical invasion, the values were 43%, 94%, 69%, 85% and 83%, respectively, for PET/CT, 33%, 95%, 60%, 85%, and 82%, respectively, for MRI, and 29%, 92%, 48%, 82% and 78% for 2DUS. Finally, for lymph node metastases, the values were 74%, 93%, 59%, 96%, and 91% for PET/CT and 59%, 93%, 40%, 97% and 90% for MRI. When comparing the diagnostic performance we found PET/CT, MRI and 2DUS to be comparable in predicting myometrial invasion. For cervical invasion and lymph node metastases, however, PET/CT was the best. CONCLUSIONS: None of the modalities can yet replace surgical staging. However, they all contributed to important knowledge and were, furthermore, able to upstage low-risk patients who would not have been recommended lymph node resection based on histology and grade alone.
U2 - 10.1016/j.ygyno.2012.11.025
DO - 10.1016/j.ygyno.2012.11.025
M3 - Journal article
C2 - 23200916
VL - 128
SP - 300
EP - 308
JO - Journal of Gynecologic Oncology Nursing
JF - Journal of Gynecologic Oncology Nursing
SN - 1536-9935
IS - 2
ER -
ID: 48466877