Moving tuberculosis vaccines from theory to practice
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Moving tuberculosis vaccines from theory to practice. / Andersen, Peter; Scriba, Thomas J.
In: Nature Reviews. Immunology, Vol. 19, 2019, p. 550–562.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Moving tuberculosis vaccines from theory to practice
AU - Andersen, Peter
AU - Scriba, Thomas J.
PY - 2019
Y1 - 2019
N2 - Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough findings in both the basic immunology of Mycobacterium tuberculosis infection and the clinical development of TB vaccines suggest, for the first time since the discovery of the Mycobacterium bovis bacillus Calmette–Guérin (BCG) vaccine more than a century ago, that a novel, efficacious TB vaccine is imminent. Here, we review recent data in the light of our current understanding of the immunology of TB infection and discuss the identification of biomarkers for vaccine efficacy and the next steps in the quest for an efficacious vaccine that can control the global TB epidemic.
AB - Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough findings in both the basic immunology of Mycobacterium tuberculosis infection and the clinical development of TB vaccines suggest, for the first time since the discovery of the Mycobacterium bovis bacillus Calmette–Guérin (BCG) vaccine more than a century ago, that a novel, efficacious TB vaccine is imminent. Here, we review recent data in the light of our current understanding of the immunology of TB infection and discuss the identification of biomarkers for vaccine efficacy and the next steps in the quest for an efficacious vaccine that can control the global TB epidemic.
U2 - 10.1038/s41577-019-0174-z
DO - 10.1038/s41577-019-0174-z
M3 - Review
C2 - 31114037
AN - SCOPUS:85066915288
VL - 19
SP - 550
EP - 562
JO - Nature Reviews. Immunology
JF - Nature Reviews. Immunology
SN - 1474-1733
ER -
ID: 226876802