Motion or activity: their role in intra- and inter-subject variation in fMRI
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Motion or activity: their role in intra- and inter-subject variation in fMRI. / Lund, Torben E; Nørgaard, Minna D; Rostrup, Egill; Rowe, James B; Paulson, Olaf B.
In: NeuroImage, Vol. 26, No. 3, 2005, p. 960-964.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Motion or activity: their role in intra- and inter-subject variation in fMRI
AU - Lund, Torben E
AU - Nørgaard, Minna D
AU - Rostrup, Egill
AU - Rowe, James B
AU - Paulson, Olaf B
PY - 2005
Y1 - 2005
N2 - Functional MRI (fMRI) carries the potential for non-invasive measurements of brain activity. Typically, what are referred to as activation images are actually thresholded statistical parametric maps. These maps possess large inter-session variability. This is especially problematic when applying fMRI to pre-surgical planning because of a higher requirement for intra-subject precision. The purpose of this study was to investigate the impact of residual movement artefacts on intra-subject and inter-subject variability in the observed fMRI activation. Ten subjects were examined using three different word-generation tasks. Two of the subjects were examined 10 times on 10 different days using the same paradigms. We systematically investigated one approach of correcting for residual movement effects: the inclusion of regressors describing movement-related effects in the design matrix of a General Linear Model (GLM). The data were analysed with and without modeling the residual movement artefacts and the impact on inter-session variance was assessed using F-contrasts. Inclusion of motion parameters in the analysis significantly reduced both the intra-subject as well as the inter-subject-variance
AB - Functional MRI (fMRI) carries the potential for non-invasive measurements of brain activity. Typically, what are referred to as activation images are actually thresholded statistical parametric maps. These maps possess large inter-session variability. This is especially problematic when applying fMRI to pre-surgical planning because of a higher requirement for intra-subject precision. The purpose of this study was to investigate the impact of residual movement artefacts on intra-subject and inter-subject variability in the observed fMRI activation. Ten subjects were examined using three different word-generation tasks. Two of the subjects were examined 10 times on 10 different days using the same paradigms. We systematically investigated one approach of correcting for residual movement effects: the inclusion of regressors describing movement-related effects in the design matrix of a General Linear Model (GLM). The data were analysed with and without modeling the residual movement artefacts and the impact on inter-session variance was assessed using F-contrasts. Inclusion of motion parameters in the analysis significantly reduced both the intra-subject as well as the inter-subject-variance
U2 - http://dx.doi.org/10.1016/j.neuroimage.2005.02.021
DO - http://dx.doi.org/10.1016/j.neuroimage.2005.02.021
M3 - Journal article
VL - 26
SP - 960
EP - 964
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 3
ER -
ID: 34057900